Mechanism of Fat Mass and Obesity-Related Gene-Mediated Heme Oxygenase-1 m6A Modification in the Recovery of Neurological Function in Mice with Spinal Cord Injury

This study explores how a gene related to obesity, FTO, influences recovery after spinal cord injury (SCI) in mice. It focuses on how FTO affects another molecule, HO-1, through a process called m6A modification. The researchers found that FTO can help reduce nerve cell death (apoptosis) and improve neurological function after SCI. They also found that FTO controls HO-1 by changing its m6A modification, which affects how stable the HO-1 molecule is. These findings suggest that targeting FTO could be a new way to treat SCI by promoting nerve cell survival and improving recovery.

• 1
  FTO overexpression improves neurological function and reduces neuronal apoptosis in SCI mice.
• 2
  FTO upregulates HO-1 expression by modulating m6A modification.
• 3
  Downregulation of HO-1 partially reverses the protective effect of FTO against OGD-induced neuronal apoptosis.