Genetics Research

KEY FINDING: Spinal cord injury (SCI) induces senescence in spinal cord microvascular endothelial cells (SCMECs).

KEY FINDING: CAPE-treated SCI mice showed less neuronal tissue loss, more neuronal survival, and reduced demyelination.

KEY FINDING: Tuberculous meningitis (TBM) can cause seizures due to elevated cerebral metabolic rate of oxygen consumption (CMRO2) and the presence of polyunsaturated fatty acids (PUFAs), rendering the brain parenchyma vulnerable to lipid peroxidation and free radical injury.

KEY FINDING: Mice with both reduced STMN2 and mutant TDP-43 (TDP-43Q331K/+) exhibited an earlier onset and more severe progressive motor deficit compared to mice with either condition alone.

KEY FINDING: MSC-Exo can effectively suppress inflammatory responses and oxidative stress following SCI, contributing to neuronal survival.

KEY FINDING: LPS treatment induced cell apoptosis and inhibited microglia polarization from M1 to M2 phenotype, accompanied by an increase of Bax protein expression and a decrease of Bcl-2 protein expression, however, these effects were relieved after SP1 silencing.

KEY FINDING: MBP84-104 interacts with and inactivates LXRα, a nuclear transcription factor that regulates cholesterol metabolism and inflammation.

KEY FINDING: Single-cell transcriptome sequencing identified VEGFR and TGF-β as therapeutic targets in chordoma.

KEY FINDING: bFGF treatment improved motor function in SCI rats, as evidenced by increased BBB scores compared to the model group.

KEY FINDING: ACOD1 attenuated neuroinflammation and oxidative stress after spinal cord injury.