Post-treatment with maropitant reduces oxidative stress, endoplasmic reticulum stress and neuroinflammation on peripheral nerve injury in rats

This study investigates the potential of maropitant, a drug commonly used to prevent vomiting, to treat neuropathic pain in rats. Neuropathic pain is a chronic condition resulting from damage to the nervous system. The researchers induced neuropathic pain in rats and then treated them with different doses of maropitant. They assessed the rats' sensitivity to pain and examined their spinal cords for signs of inflammation, oxidative stress, and endoplasmic reticulum stress. The study found that maropitant, at a specific dose, reduced pain sensitivity and improved several markers associated with nerve damage, suggesting it could be a potential treatment for neuropathic pain.

• 1
  Maropitant inhibited nociception with an ID50 value of 4.1 mg/kg in a neuropathic pain model induced by chronic constriction injury (CCI).
• 2
  A dose of 30 mg/kg/24q of maropitant significantly reduced mechanical allodynia, with nociception inhibition of 145.83%.
• 3
  Maropitant treatment reduced the expression of hypoxia factors (HIF1α, Nrf2), inflammatory markers (IL10, TNFα), microglial (IBA-1), and neuronal markers (NeuN, TACR1).