Genetics Research

KEY FINDING: B9 alleviates mechanical pain after SCI. Intrathecal administration of B9, starting at 1 day postinjury (dpi) until 7 dpi, attenuates mechanical pain in hindlimbs at 3 weeks pi.

KEY FINDING: Deficits in mitochondrial function and metabolism are considered driving forces in progressive energy crisis developed after TBI.

KEY FINDING: Burn injuries can lead to CNS-related sequelae, including neural apoptosis, hyperalgesia, and changes in metabolism and cognitive function.

KEY FINDING: The p38 MAPK signaling pathway is involved in multiple processes of IDD, including inflammation, ECM degradation, apoptosis, senescence, proliferation, oxidative stress, and autophagy.

KEY FINDING: TLR4 deletion reduces neuronal and myelin loss, decreasing secondary damage at 8 weeks post-SCI.

KEY FINDING: The study identified distinct lipid fingerprints in the lesion core, peri-lesion (the lesion front rich in infiltrating cells), and uninvolved tissue, demonstrating a clear difference in lipid signature between the lesion front and the epicentre.

KEY FINDING: IL-38 alleviates neuromyelitis optica disorder (NMOD) by inhibiting Th17 expression.

KEY FINDING: AF injury induces acute inflammation in the spine, DRG, and spinal cord, followed by chronic glial responses in the DRG and spinal cord.

KEY FINDING: MiR-211-5p targets COX2 mRNA and regulates its protein expression in BMSCs, suggesting a role in controlling inflammation.

KEY FINDING: CPTX expression in transplanted hiPSC-NS/PCs significantly increased excitatory synapse formation at the transplantation site.