Genetics Research

KEY FINDING: Acacetin treatment improved motor function in SCI mice, as evidenced by higher BMS scores and improved mechanical and thermal hypersensitivity.

KEY FINDING: M1 macrophages exacerbate SCI by secreting inflammatory factors, while M2 macrophages promote tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors.

KEY FINDING: Targeted FGF22 overexpression in long propriospinal neurons enhances excitatory synapse formation, increasing the number of vGlut1-expressing presynaptic boutons.

KEY FINDING: EX-4 improves motor function and limb strength, and promotes the recovery of autophagy flux after spinal cord injury in rats.

KEY FINDING: Several natural compounds can activate Nrf2 through multiple pathways, inducing a strong antioxidant response against CNS trauma.

KEY FINDING: miR-491-3p acts as a tumor suppressor gene in RB, inhibiting the growth and metastasis of tumors by targeting SNN.

KEY FINDING: Physiological EF stimulation (100 mV/mm) significantly boosts neuronal differentiation of NSCs in vitro, increasing MAP2 positive cells and neuronal process length.

KEY FINDING: 3,4-DC reduced glial scar area and motor neuron death and improved functional recovery after SCI.

KEY FINDING: SCI induces endothelial ALP dysfunction, disrupting the balance of autophagy in endothelial cells, which are critical components of the BSCB.

KEY FINDING: CircFhit, an exon-intron circRNA, is upregulated in the spinal dorsal horn in a neuropathic pain model and contributes to neuropathic pain following spared nerve injury (SNI).