Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 311-320 of 1,773 results
Biomaterials Research, 2023 • January 1, 2023
The study explores the therapeutic potential of engineered exosomes (EX) enriched with netrin-1 modRNA in treating spinal cord injury (SCI). In vitro experiments demonstrated that EX-netrin1 attenuate...
KEY FINDING: EX-netrin1 regulated inflammation, pyroptosis and axon growth in SCI via the Unc5b/PI3K/AKT/mTOR pathway.
The Journal of Neuroscience, 2023 • March 1, 2023
This study demonstrates the beneficial effects of AAV-mediated transduction with NG2Ab for neutralization of inhibitory function of NG2 proteoglycan, combined with AAV-mediated transduction with neuro...
KEY FINDING: AAV-NG2Ab and AAV-NT3 treatment improved locomotor function after contusion SCI.
Cellular & Molecular Biology Letters, 2023 • January 5, 2023
This study investigates the potential mechanism by which PBM regulates the polarization of BMDMs, we identified a critical ceRNA network and explored its function. The study clarified that lncRNA TUG1...
KEY FINDING: LncRNA TUG1 is a potential target of PBM, regulating the polarization of BMDMs, inflammatory response, and the axial growth of DRG.
Ann Transl Med, 2022 • December 1, 2022
In ipsilateral L4-L6 DRGs, SNI-induced activation of macrophages was accompanied by reduced autophagy. EA alleviated SNI-induced NP and activated the autophagy process in DRG macrophages. These result...
KEY FINDING: SNI achieved a significant upregulation of autophagy levels in DRG macrophages.
J Cell Mol Med, 2023 • January 1, 2023
This study investigates the therapeutic impact of PrPcOE-ADMSCs on protecting the integrity of the spinal cord against acute SCI in rodents and observed that the NLRP3 inflammasome and DAMP-inflammato...
KEY FINDING: PrPcOE-ADMSCs showed enhanced cellular viability, anti-oxidative stress, and migration capabilities compared to ADMSCs alone when exposed to H2O2 and lipopolysaccharide damages.
Journal of Translational Medicine, 2024 • July 3, 2024
This study unveils the critical regulatory role of miR-223 in lipid homeostasis following SCI. The mechanism by which this occurs involves the upregulation of ABCA1 expression, which facilitates LDs c...
KEY FINDING: Lipid droplets accumulate in microglia at the injury epicenter post-SCI.
Biomedicines, 2023 • January 13, 2023
This review summarizes preclinical studies that show the effects of MSC-EXOs as a new molecular target to counteract the devastating effects of SCI. The studies reported that MSC-EXOs can exert anti-i...
KEY FINDING: MSC-EXOs possess anti-inflammatory and anti-apoptotic effects, facilitate axonal regeneration, and modulate macrophage polarization, protecting the blood-spinal cord barrier.
Genes, 2023 • January 9, 2023
This study reports the identification and characterization of a new member of the zebrafish ZBED protein family, named ZBEDX, which is encoded by the previously uncharacterized Zgc:161969 gene. The st...
KEY FINDING: The LOC569044 protein, encoded by the Zgc:161969 gene, is identified as a new member of the zebrafish ZBED protein family and named ZBEDX.
Frontiers in Cellular Neuroscience, 2023 • January 4, 2023
The study aimed to explore the neuroprotective effect of Schwann cells-derived exosomes (SCs-Exos) on spinal cord injury (SCI). The researchers found that SCs-Exos can be directly taken up by brain-de...
KEY FINDING: SCs-Exos are absorbed by brain-derived endothelial cells (bEnd.3), promoting their proliferation, migration, and tube formation.
J Clin Invest, 2023 • March 1, 2023
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropat...
KEY FINDING: TRPV4 is functionally expressed in spinal resident microglia and its expression is increased in a mouse model of spared nerve injury (SNI).