Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 291-300 of 1,773 results
Oxidative Medicine and Cellular Longevity, 2022 • November 23, 2022
This study investigates the role of macrophage extracellular traps (Mets) in secondary spinal cord injury (SCI). The research demonstrates that Mets exacerbate inflammation by promoting M1 polarizatio...
KEY FINDING: Macrophages in the injured spinal cord release Mets, which contribute to the differentiation of macrophage/microglia into M1-like cells, exacerbating inflammation.
Ann Transl Med, 2022 • November 1, 2022
This study investigated the potential of Astragaloside IV (AS-IV) to alleviate spinal cord injury (SCI) by controlling ferroptosis in H2O2-damaged PC12 cells in vitro. The results indicated that AS-IV...
KEY FINDING: AS-IV treatment (1.0 μM for 48 h) significantly increased the viability of PC12 cells and enhanced their proliferation.
Bioactive Materials, 2023 • January 1, 2023
This study introduces a novel drug delivery system using peptide CAQK-modified, siRNA-loaded EVs (C-EVs-siRNA) for targeted therapy of spinal cord injury (SCI). The C-EVs-siRNA specifically targeted t...
KEY FINDING: The study demonstrates that CAQK-modified, siRNA-loaded EVs (C-EVs-siRNA) can specifically deliver siRNA to the SCI region and be taken up by target cells.
Journal of Neurotrauma, 2023 • May 1, 2023
This study demonstrates that acute pharmacological inhibition of PERK signaling after SCI spares oligodendrocytes and improves locomotor recovery in mice. The findings suggest that excessive acute act...
KEY FINDING: Acute inhibition of PERK with GSK2656157 after SCI reduced ER stress, improved white matter sparing, and enhanced hindlimb locomotion recovery in mice.
Neural Plasticity, 2022 • October 19, 2022
This study investigated the effect of exercise on neuropathic pain in mice with spared nerve injury (SNI). The researchers examined pain behavior and molecular changes in the spinal cord. The study fo...
KEY FINDING: Spared nerve injury (SNI) led to mechanical and cold allodynia, elevated expression of latency-associated peptide- (LAP-) TGF-β1, and activated astroglial in the spinal cord.
Frontiers in Cellular Neuroscience, 2022 • November 23, 2022
This study aimed to modulate the inflammatory milieu in spinal cord injury (SCI) by using lipopolysaccharide (LPS) and granulocyte colony-stimulating factor (G-CSF) to improve bone-marrow mesenchymal ...
KEY FINDING: Medium-dose LPS administration resulted in a local anti-inflammatory beneficial role, associated with increased NF-200-positive cells, tissue sparing, and improved functional recovery.
Oxidative Medicine and Cellular Longevity, 2022 • December 2, 2022
This review discusses the detailed mechanisms of ferroptosis and summarizes current researches on ferroptosis with respect to nerve injury, aiming at providing new insights on targeting ferroptosis fo...
KEY FINDING: Ferroptosis involves iron overload, lipid peroxidation, ROS generation, and mitochondrial changes, contributing to nerve damage in PNI.
Journal of Orthopaedic Surgery and Research, 2022 • December 5, 2022
This study investigates the potential of Astragaloside IV (AS IV) to treat intervertebral disc degeneration (IDD) by alleviating inflammation, apoptosis, and extracellular matrix (ECM) degeneration in...
KEY FINDING: AS IV effectively alleviated IL-1β-induced inflammation, apoptosis, and extracellular matrix degeneration in NPCs.
Int. J. Mol. Sci., 2022 • December 14, 2022
This study demonstrates that loganin, an iridoid glycoside, can modulate autophagic flux in a rat model of chronic constriction injury (CCI)-induced neuropathic pain. The results indicate that loganin...
KEY FINDING: Loganin attenuated the expression of Beclin-1, LC3B-II, and p62 in CCI rats, suggesting an improvement in autophagic flux.
Brain and Behavior, 2023 • January 1, 2023
This study shows that oxidative stress plays an important role in the cytoskeleton destruction of spinal motor neurons in SCI, and treatment of SCI on this basis is a promising strategy. These finding...
KEY FINDING: H2O2 caused severe damage to the normal cytoskeleton, leading to a reduction in neurite length and number, rearrangement of the actin cytoskeleton, and disorder of the microtubules and neurofilaments in VSC4.1.