Endocrinology Research

KEY FINDING: The study hypothesizes that TT+LPWS will upregulate protein synthesis pathways, downregulate protein degradation pathways, and increase overall mitochondrial health in denervated muscles.

KEY FINDING: Skeletal regeneration is sexually dimorphic: female mice require estrogen for skeletal stem cell-mediated bone regeneration, while male mice do not exhibit similar estrogen responsiveness.

KEY FINDING: The review highlights the complex microenvironment of DFUs, characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and high protease activity, all hindering the normal wound healing process.

KEY FINDING: PfKelch13 mutant parasite lines exhibit reduced susceptibility to DHA and prolonged ring stage.

KEY FINDING: Dock3 mKO mice presented with significant hyperglycemia and increased fat mass, indicating a metabolic role in the maintenance of skeletal muscle health.

KEY FINDING: P2RY12 deficiency protects mice from ConA-induced immune hepatitis by reducing serum ALT and AST levels, blocking the increases of serum IFN-γ, IL-12p70, IL-6, and TNF-α, and decreasing serum IL-10.

KEY FINDING: MET reduces cell proliferation and mitochondrial respiration in MYCN-amplified NB cell lines.

KEY FINDING: Expression levels of IL-6, sIL-6R, IL-17A, IL-8, MCP-1, TNF-b, RANTES, TIMP-1, and TIMP-2 were significantly higher in DC patients compared with ARC patients.

KEY FINDING: The patient gained 5.0 kg of lean body mass after the 3-month therapy.

KEY FINDING: Identified 512 upregulated and 254 downregulated DEGs in patients with PSID compared with controls, significantly associated with immune- and metabolism-related biological processes and pathways.