Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 191-200 of 217 results
Lipids in Health and Disease, 2023 • October 2, 2023
This study identified a novel frameshift insertion in the LDLR gene and several variants in the APOB gene in a Chinese family with familial hypercholesterolemia. The cumulative effect of these genetic...
KEY FINDING: A novel frameshift insertion (c.497delinsGGATCCCCCAGCTGCATCCCCCAG: p. Ala166fs) was identified in the LDLR gene, preventing proper expression of LDLR on the cell membrane.
Frontiers in Endocrinology, 2023 • November 8, 2023
This study employed Mendelian randomization to investigate the causal relationship between sarcopenic obesity (SO) factors and benign prostatic hyperplasia (BPH), focusing on basal metabolic rate (BMR...
KEY FINDING: An increase in BMR is associated with an elevated risk of developing BPH.
JCI Insight, 2024 • March 7, 2024
This study evaluated the therapeutic potential of nicotinamide riboside (NR) supplementation in a transgenic mouse model of spinal and bulbar muscular atrophy (SBMA). The researchers aimed to increase...
KEY FINDING: NR supplementation failed to ameliorate motor dysfunction or muscle pathology in a transgenic mouse model of SBMA.
Frontiers in Endocrinology, 2024 • May 10, 2024
This study uses Mendelian randomization (MR) to explore the causal relationships between hormonal and reproductive factors (ANM, AAM, LMC, AFB, AFS, ALB) and the prevalence of low back pain (LBP). The...
KEY FINDING: AAM (OR=0.784, 95% CI: 0.689-0.891; p=3.53E-04), AFB (OR=0.558, 95% CI: 0.436-0.715; p=8.97E-06), ALB (OR=0.396, 95% CI: 0.226-0.692; p=0.002), and AFS (OR=0.602, 95% CI: 0.518-0.700; p=3.47E-10) were associated with a decreased risk of LBP.
Metabolic Brain Disease, 2024 • July 9, 2024
This study used lipidomics and metabolomics to investigate lipid and metabolite changes in the spinal cords of diabetic rats with painful neuropathy. The results showed dysregulation of 170 metabolite...
KEY FINDING: Dysregulation of 170 metabolites and 45 lipids was observed in the spinal cords of rats with painful diabetic neuropathy (PDN).
Scientific Reports, 2024 • November 25, 2024
This study examined the potential of GnRH and GH treatments to promote neurotrophic and synaptic recovery in ovariectomized rats with thoracic SCI. The results showed that chronic administration of Gn...
KEY FINDING: GnRH and GH treatments upregulate the expression of neurotrophic and synaptogenic activity genes in rats with SCI.
PLoS ONE, 2015 • February 17, 2015
This study examined the time-course effect of electrical stimulation (ES) on nerve regeneration in streptozotocin (STZ)-induced diabetic rats after peripheral nerve transection and repair using silico...
KEY FINDING: Immediate onset of electrical stimulation (ES) after nerve repair in diabetic rats significantly improved nerve regeneration across a 10-mm nerve gap compared to delayed or no ES.
PNAS, 2016 • December 20, 2016
This study reveals a critical role for testosterone and the androgen receptor (AR) in the regeneration of myelin in the central nervous system (CNS). It demonstrates that testosterone, signaling throu...
KEY FINDING: Testosterone and the androgen receptor (AR) are essential for the recruitment of astrocytes into demyelinated lesions in the CNS of male mice.
Neural Regeneration Research, 2017 • March 1, 2017
The study aimed to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain using a rat model of chronic sciatic nerve constriction injury. Rats administered estrad...
KEY FINDING: Estrogen administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve.
MOLECULAR MEDICINE REPORTS, 2018 • January 1, 2018
This study aimed to explore the therapeutic effects of CsA on SCI in rats with hyperglycemia and to identify a novel potential method to treat SCI in the presence of hyperglycemia. The results demonst...
KEY FINDING: CsA significantly improved neurological function in SCI rats with hyperglycemia.