Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 171-180 of 217 results
The Journal of Spinal Cord Medicine, 2013 • January 1, 2013
This study investigated the effects of nandrolone, an anabolic steroid, on bone loss in rats after spinal cord injury (SCI). The results showed that nandrolone attenuated bone loss after SCI, suggesti...
KEY FINDING: SCI reduced distal femoral and proximal tibial bone mineral density (BMD) by 25 and 16%, respectively, at 56 days.
PM R, 2014 • May 1, 2014
Assessment of BMD in children is challenging because of the limitations of DXA in evaluating the growing skeleton. Increasing evidence suggests that bisphosphonates may be beneficial for pediatric dis...
KEY FINDING: Data suggest short-term improvements in BMD, whereas effects on fracture risk remain an area of debate.
Top Spinal Cord Inj Rehabil, 2007 • January 1, 2007
The prevalence of obesity is increasing, including in individuals with spinal cord injuries (SCI). BMI may not accurately reflect obesity in SCI due to changes in body composition; percent body fat is...
KEY FINDING: Obesity prevalence may be underestimated or unclearly defined following SCI due to the lack of a valid differential tool.
Cell Regeneration, 2021 • March 15, 2021
This study investigates the expression and function of the melanocortin 4 receptor (MC4R) in mouse limb and digit regeneration. It utilizes Mc4r-gfp mice to track MC4R expression during development an...
KEY FINDING: Mc4r expression in the mouse limb and digit is closely related to nerve tissues.
Oxidative Medicine and Cellular Longevity, 2021 • July 31, 2021
Our results sug- gested that zinc enhanced the glucose uptake of the injured neurons and spinal cord, reduced oxidative stress and neuro- nal apoptosis, promoted mitochondrial biogenesis, and encourag...
KEY FINDING: zinc elevated the expression level of GLUT4 and promoted glucose uptake.
Endocrine Connections, 2021 • October 22, 2021
This study investigates the evolutionary conservation and functional divergence of two homologous MC3Rs in the allotetraploid frog Xenopus laevis in vitro. The study clarified the interaction between ...
KEY FINDING: xlMRAP2.L/S enhances α-MSH-stimulated xlMC3Rs signaling and reduces their surface expression.
European Journal of Histochemistry, 2021 • August 13, 2021
This study evaluated the impact of unacylated ghrelin (UnAG) on peripheral nerve regeneration in mice after crush and transection injuries. The researchers used transgenic mice with overexpression of ...
KEY FINDING: Healthy mice with elevated UnAG levels showed differences in nerve structure compared to normal mice, suggesting a role for UnAG in nerve development. Specifically, UnAG median nerves have a higher density and smaller myelinated fibres than WT nerves.
Frontiers in Endocrinology, 2022 • February 17, 2022
This study comprehensively examined and elucidated the pharmacological and physiological regulation of central melanocortin signaling in the axolotl. The study found a relatively conserved protein str...
KEY FINDING: Axolotl MC3R and MC4R can be activated by a-MSH and ACTH. Axolotl MC3R exhibited a high constitutive activity, that was significantly decreased by MRAP2
Frontiers in Endocrinology, 2022 • June 30, 2022
This study investigates the role of CD137 in age-related bone loss and senile osteoporosis. Through bioinformatics analysis of gene expression datasets, CD137 was identified as a potential key gene in...
KEY FINDING: Aged mice (18-month-old) exhibited significant bone loss compared to young mice (6-month-old), along with a tenfold increase in adipose tissue in the bone marrow cavity.
J Mol Endocrinol, 2022 • November 1, 2022
Retinoic acid (RA) signaling, mediated by nuclear RA receptors (RARs), is crucial for embryonic development. RA's role was discovered through observations of its teratogenic effects and later confirme...
KEY FINDING: RA signaling is required for normal early development of many organs and tissues, including the hindbrain, posterior body axis, somites, spinal cord, forelimbs, heart, and eye.