Am J Case Rep, 2015 · DOI: 10.12659/AJCR.893901 · Published: October 27, 2015
This case report explores the potential of oxandrolone, an anabolic steroid, to promote nerve regeneration in a patient with Charcot-Marie-Tooth disease type 1 (CMT1). CMT1 is a demyelinating disease affecting the peripheral nerves, leading to muscle weakness and sensory loss. The patient received oxandrolone (20 mg/day) for 3 months in combination with exercise. Results showed increased muscle strength, improved walking ability and indicators of muscle regeneration on biopsy. The findings suggest that oxandrolone may have a neuroregenerative effect by promoting myelin synthesis and improving neuromuscular efficiency. This could offer a potential treatment strategy for demyelinating diseases and other neuromuscular conditions.
Oxandrolone may be a potential therapeutic strategy for promoting nerve regeneration and improving neuromuscular function in patients with demyelinating diseases.
Oxandrolone could be considered within rehabilitation programs for patients with neuromuscular damages, such as hereditary neuropathy, aging, and after peripheral injury.
Further research is warranted to investigate the neuroregenerative effects of oxandrolone and its potential benefits for various neuromuscular conditions.