Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 301-310 of 339 results
Neural Regeneration Research, 2023 • November 9, 2022
This study demonstrates that aging impairs neurological recovery and angiogenesis following spinal cord injury (SCI) in mice. Metformin, a common drug for type 2 diabetes, was found to promote angioge...
KEY FINDING: Aging hinders neurological function recovery and blood vessel formation in the spinal cord after injury.
Neurospine, 2022 • December 1, 2022
Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functiona...
KEY FINDING: Five main therapeutic approaches to diminish hypoxia-ischemia and promote vascular repair were identified as (1) the application of angiogenic factors, (2) genetic engineering, (3) physical stimulation, (4) cell transplantation, and (5) biomaterials carrying various factor delivery.
AGING, 2023 • February 1, 2023
This study investigated the impact of short-term platelet depletion on Alzheimer's disease neuropathology in APP-PS1 mice. The researchers found that platelet depletion in female APP-PS1 mice augmente...
KEY FINDING: Platelet depletion in APP-PS1 female mice shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus.
Frontiers in Neuroanatomy, 2023 • March 21, 2023
This study quantified structural changes in capillary morphology and microstructure from the acute to chronic stages of SCI, providing insights into the microvascular pathology and potential targets f...
KEY FINDING: Acute microvascular disruption was evident post-SCI, particularly at the injury epicentre, spreading three spinal segments rostrally and caudally.
Int. J. Mol. Sci., 2023 • March 29, 2023
This study explores the vascular response after traumatic spinal cord injury (SCI) in mice, focusing on the subacute injury phase (3-7 days post-injury) when the blood-spinal cord barrier (BSCB) is ab...
KEY FINDING: Cd9 and Mylip genes were identified as differentially expressed at 3 and 7 days post-injury (dpi) in a mouse contusion model of spinal cord injury.
Spinal Cord Series and Cases, 2023 • June 22, 2023
This case report describes a patient with a C6 spinal cord injury who experienced recurrent syncope due to autonomic dysfunction. Investigations revealed impaired sympathetic and cardiovagal responses...
KEY FINDING: The patient experienced frequent syncopal events with low blood pressure, despite initial treatment for orthostatic hypotension.
Frontiers in Molecular Biosciences, 2023 • June 30, 2023
This study investigated platelet activation, proteome, and transcriptome in Alzheimer’s disease (AD) patients, non-demented elderly, and young individuals to understand the molecular mechanisms underl...
KEY FINDING: AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls.
Lipids in Health and Disease, 2023 • October 2, 2023
This study identified a novel frameshift insertion in the LDLR gene and several variants in the APOB gene in a Chinese family with familial hypercholesterolemia. The cumulative effect of these genetic...
KEY FINDING: A novel frameshift insertion (c.497delinsGGATCCCCCAGCTGCATCCCCCAG: p. Ala166fs) was identified in the LDLR gene, preventing proper expression of LDLR on the cell membrane.
Heliyon, 2023 • October 13, 2023
The study demonstrated that intravenously administered RIPCs significantly improved neuropathic pain symptoms, specifically thermal hyperalgesia and mechanical allodynia, in rats with partial sciatic ...
KEY FINDING: Intravenous administration of RIPCs was most effective in reducing thermal hyperalgesia and mechanical allodynia in rats with neuropathic pain.
Heliyon, 2023 • October 27, 2023
This study evaluated the regulatory effect of Tetramethylpyrazine (TMP) on the spinal cord injury (SCI) rat model and clarified the neuroprotective mechanism of TMP on SCI. The study results presented...
KEY FINDING: TMP promotes angiogenesis, nerve regeneration, and repair of nerve defects in SCI rats.