Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 1-10 of 339 results
Biomech Model Mechanobiol, 2012 • January 1, 2012
This study examined the impact of mechanical strain and TGF-β1 on urinary bladder wall smooth muscle remodeling using an ex vivo organ culture system. Results showed that a 0.5-Hz strain induced elast...
KEY FINDING: A 0.5-Hz strain frequency triangular waveform stimulation at 15% strain resulted in fibrillar elastin production, collagen turnover, and a more compliant ECM.
Journal of Cerebral Blood Flow & Metabolism, 2012 • August 1, 2012
This study investigates the role of pericytes in the blood–spinal cord barrier (BSCB). It demonstrates that pericyte coverage and number are reduced in spinal cord capillaries compared to the brain, p...
KEY FINDING: Spinal cord capillaries, especially in the anterior horn, have fewer pericytes compared to brain capillaries in wild-type mice.
Nat Med, 2012 • November 1, 2012
Angiogenesis is a key feature of central nervous system injury. A neovessel-derived signal mediated by prostacyclin triggers axonal sprouting and functional recovery in a mouse model of inflammatory s...
KEY FINDING: Neovessels are formed in perilesional tissue in both inflammatory and traumatic spinal cord injury3,4. In this issue of Nature Medicine, Muramatsu et al.5 use a highly targeted inflammatory injury to the thoracic spinal cord that damages descending corticospinal tract (CST) projections from the brain to model some aspects of human multiple sclerosis.
The Journal of Neuroscience, 2013 • October 23, 2013
This study investigates the potential of embryonic neural stem cell grafts to restore cardiovascular function after complete spinal cord transection in adult rats. The key finding is that brainstem-de...
KEY FINDING: Grafting brainstem-derived neural stem cells (BS-NSCs) resulted in recovery of basal cardiovascular parameters in rats with complete spinal cord transection.
Neural Regen Res, 2012 • July 1, 2012
This study used proteomic analysis to investigate protein expression changes in a rabbit model of spinal cord ischemia/reperfusion injury. The researchers identified 23 differentially expressed protei...
KEY FINDING: In the ischemia group, eight proteins were upregulated, and four were downregulated compared to the sham-surgery group.
Neural Regeneration Research, 2014 • December 1, 2014
Melatonin has been shown to diminish edema in rats. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i...
KEY FINDING: Melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord after spinal cord injury.
Cell Cycle, 2015 • July 15, 2015
The study demonstrates that nestin-expressing HAP stem cells, located in the hair follicle, can differentiate into beating cardiac muscle cells in vitro. The upper part of the hair follicle shows the ...
KEY FINDING: HAP stem cells from mouse vibrissa hair follicles can differentiate into beating cardiac muscle cells.
Thorac Cardiovasc Surg, 2025 • June 11, 2024
Deep hypothermia helps protect the spinal cord, but is invasive. The motor evoked potential disappeared during aortic clamping in nine patients. Six patients recovered completely from aortic clamping ...
KEY FINDING: The motor evoked potential disappeared during aortic clamping in nine patients.
BMC Cardiovascular Disorders, 2025 • January 21, 2025
This retrospective study of 447 ATAAD patients undergoing urgent TAR and FET found that MI-HCA was associated with shorter CPB time and reduced blood transfusion needs. MI-HCA patients had better post...
KEY FINDING: MI-HCA was associated with a shorter CPB time, and reduced blood transfusion requirements.
Cureus, 2024 • December 18, 2024
The case report highlights a rare anatomical variation where the vertebral artery originates from the internal carotid artery, potentially leading to posterior circulation neurological deficits if the...
KEY FINDING: A dominant right vertebral artery was found to originate from the right internal carotid artery in a 76-year-old female.