Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 311-320 of 339 results
Neural Regen Res, 2024 • August 1, 2024
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions. Neur...
KEY FINDING: NETs are key mediators of inflammation and thrombosis, and have been widely accepted as a mechanism of deep vein thrombosis.
Cellular and Molecular Life Sciences, 2024 • February 18, 2024
This study investigates the role of the deubiquitinase UCHL1 in promoting angiogenesis and blood-spinal cord barrier (BSCB) function recovery after spinal cord injury (SCI) by stabilizing Sox17. The f...
KEY FINDING: Sox17 is predominantly localized in endothelial cells and is significantly upregulated after SCI and in LPS-treated brain microvascular endothelial cells.
Advanced Science, 2024 • September 28, 2024
This study demonstrates that traumatic pathological vascular remodeling occurs during the chronic phase of injury, characterized by enlarged vessel diameter, disruption of blood-spinal cord barrier, e...
KEY FINDING: Traumatic SCI leads to pathological vascular remodeling, including enlarged vessel diameter and disruption of the blood-spinal cord barrier.
Journal of Nanobiotechnology, 2024 • August 22, 2024
This study investigates the role of spinal cord-derived microvascular endothelial cells (SCMECs) in promoting axon growth after spinal cord injury (SCI). The researchers found that SCMECs promote axon...
KEY FINDING: SCMECs promote axon outgrowth in a non-contact fashion by downregulating miR-323-5p expression in neurons.
Journal of Cellular Physiology, 2025 • January 1, 2025
This review highlights the significance of pericytes in spinal cord injury (SCI) repair, focusing on their role in vascular regeneration and interaction within the neurovascular unit (NVU). Pericytes ...
KEY FINDING: Pericytes are essential for maintaining the integrity of the spinal cord vasculature after SCI by providing neuroprotection, maintaining stem cell pluripotency, and promoting angiogenesis and vessel maturation.
Brain and Spine, 2025 • January 23, 2025
This study comprehensively examines the temporospatial dynamics of vascular injury and regeneration following experimental spinal cord injury (SCI) in mice, focusing on changes in vascular density, pe...
KEY FINDING: Vascular injury is most severe initially at the epicenter and spreads to surrounding spinal cord regions, with a delayed vascular loss observed in peritraumatic regions.
Cell Reports Medicine, 2025 • March 18, 2025
The study develops injectable GelMA hydrogels with controlled mechanical properties containing targeting miR-222-engineered extracellular vesicles (TeEVs). These injectable patches facilitate the prec...
KEY FINDING: Targeting miR-222-engineered EVs are incorporated in mechanical GEL hydrogels
Journal of Neurochemistry, 2025 • February 3, 2025
The study introduces a novel tamoxifen-inducible PDGFRβ+ cell ablation model in mice to investigate pericyte responses in the CNS following acute ablation, addressing limitations in existing models. T...
KEY FINDING: A low dose of tamoxifen effectively ablates PDGFRβ+ cells of the CNS in mice without reducing survival or causing significant systemic side effects, such as weight loss.
Journal of Clinical Laboratory Analysis, 2015 • January 1, 2015
This retrospective study compared three different test systems (ELISA, solid-phase assay, and LCT) for detecting platelet antibodies in 1,234 patient samples. The results showed significant divergence...
KEY FINDING: Platelet antibodies were detected in 29.7% of the 1,234 samples tested.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
This study demonstrates that acute SCI induces a systemic response characterized by increased circulating EPCs and ECs, along with altered levels of chemoattractive and proangiogenic factors. Gene exp...
KEY FINDING: Spinal cord injury (SCI) triggers the mobilization of bone marrow-derived endothelial progenitor cells (EPCs), leading to a higher count of EPCs in the peripheral blood of patients within 7 days post-injury.