Neural Regeneration Research, 2023 · DOI: 10.4103/1673-5374.360245 · Published: November 9, 2022
This study investigates the effect of metformin on spinal cord injury in aged mice, focusing on angiogenesis. The researchers hypothesized that metformin promotes blood vessel regeneration in aged mice after spinal cord injury by activating a specific pathway (AMPK/eNOS). The study found that metformin improves neurological function in aged mice after spinal cord injury by promoting blood vessel formation via the AMPK/eNOS pathway.
Metformin shows promise as a therapeutic agent for promoting angiogenesis and functional recovery in aged individuals after spinal cord injury.
The AMPK/eNOS pathway may be a valuable target for developing therapies to enhance vascular regeneration and neurological outcomes after SCI.
Further research is needed to fully understand the mechanisms by which aging impacts angiogenesis and recovery after SCI, which could lead to more targeted interventions.