Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 291-300 of 339 results
Top Spinal Cord Inj Rehabil, 2014 • January 1, 2014
This pilot study investigated the relationship between dietary intake and cardiovascular disease (CVD) risk factors in individuals with chronic spinal cord injury (SCI) compared to able-bodied control...
KEY FINDING: SCI participants had significantly larger waist circumference compared to the control group (39.2 vs 36.2 in.; P < .001).
International Journal of Molecular Sciences, 2021 • April 9, 2021
This study demonstrates that both cell culture oxygen conditions and the mode of EV preparation significantly affect the function of human iPSC-EVs. Hypoxic conditioning of human iPSCs resulted in the...
KEY FINDING: iPSC-EVs derived from 1% oxygen culture exhibit significantly elevated angiogenic potential compared to EVs obtained at higher oxygen levels.
npj Regenerative Medicine, 2021 • July 2, 2021
This study demonstrates that adult X. tropicalis can regenerate heart tissue after ventricular apex resection, primarily through cardiomyocyte proliferation. RNA-seq analysis identified Fosl1 as a key...
KEY FINDING: Cardiomyocyte proliferation greatly contributes to heart regeneration in adult X. tropicalis upon apex resection.
Cell Death and Disease, 2021 • September 3, 2021
This study profiles transcriptomes and proteomes in a mouse model of AMI, revealing early immune system activation and pyroptosis. VX-765, a pyroptosis inhibitor, reduced infarct size and improved hea...
KEY FINDING: Immune system activation and subsequent pyroptosis occur in the early stages (6-24 hours) of AMI in a mouse model.
Cells, 2021 • October 7, 2021
This study systematically reviews experimental treatments for oedema following spinal cord injury (SCI). It identifies key modalities such as selective inhibition of aquaporin 4 (AQP4), modulation of ...
KEY FINDING: Selective inhibition of aquaporin 4 (AQP4), modulation of inflammation, and surgical interventions are key modalities that attenuate oedema following spinal cord injury.
Cells, 2021 • November 26, 2021
This study introduces a scalable workflow for purifying immunomodulatory AML-EVs and compares their phenotype and function to parental AML cells and secreted soluble factors. AML-EVs were enriched usi...
KEY FINDING: AML-EVs showed a significant dose-dependent inhibition of T cell proliferation, unlike AML cells or their soluble factors.
Journal of Extracellular Vesicles, 2022 • March 2, 2022
This study investigates the functional role of the protein corona surrounding extracellular vesicles (EVs) derived from human placental-expanded (PLX) stromal cells. The researchers found that this co...
KEY FINDING: PLX-EVs are surrounded by a functional protein corona when enriched with permissive technology, containing immunomodulatory and proangiogenic proteins.
Cureus, 2022 • May 30, 2022
Spinal cord injuries (SCI) initiate a complex pathological process, necessitating a comprehensive understanding of intrinsic procedures for ensuring optimal treatment and recovery conditions. Vascular...
KEY FINDING: Endogenous angiogenesis, while triggered by SCI and ischemia, is frequently inadequate to address the progressive local ischemia and cell death.
Inflammation and Regeneration, 2022 • September 2, 2022
This study investigates the mechanism of pericyte-fibroblast transition after spinal cord injury (SCI) and the role of the PDGF-BB/PDGFRβ signaling pathway in this process. The results show that micro...
KEY FINDING: PDGFRβ+ pericytes detach from blood vessel walls and transition into fibroblasts to form fibrotic scar after SCI, indicating a key role in scar formation.
Diagnostics, 2022 • October 22, 2022
The study analyzed 189 convalescent plasma (CP) donations from 66 donors to determine the optimal time span for CP donation based on anti-SARS-CoV-2 anti-S IgG antibody levels. It found a significant ...
KEY FINDING: There is a significant correlation between semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality.