Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 331-339 of 339 results
Neural Regen Res, 2018 • May 1, 2018
This study demonstrates that endothelial progenitor cell-conditioned medium (EPC-CM) exerts anti-inflammatory effects, promotes angiogenesis, and provides neuroprotection in a rat model of spinal cord...
KEY FINDING: EPC-CM reduces inflammation by decreasing M1 macrophage activation and the release of pro-inflammatory cytokines.
Frontiers in Neuroscience, 2020 • March 3, 2020
This study investigated the role of platelets in Alzheimer's disease (AD) using APP-PS1 transgenic mice, which exhibit severe amyloid plaque formation. The research focused on the presence, location, ...
KEY FINDING: APP-PS1 mice showed a higher number of platelets in the brain parenchyma compared to WT controls, indicating platelet invasion into the brain.
Scientific Reports, 2020 • May 6, 2020
This study investigates the role of miRNAs in lipedema by comparing the extracellular miRNA profiles of SVF cells from healthy individuals and lipedema patients. The results showed that sEV-contained ...
KEY FINDING: sEVs showed no significant difference in size or concentration between healthy and lipedema patients.
PLOS ONE, 2020 • August 11, 2020
This study investigated the efficacy of nonviral retrograde gene transfer of human hepatocyte growth factor (HGF) in improving ischemic neuropathy using a rat model of ischemic-reperfusion nerve injur...
KEY FINDING: HGF gene transfer significantly improved mechanical allodynia and thermal hyperalgesia in rats with ischemic-reperfusion nerve injury (IRI).
Journal of Molecular Neuroscience, 2021 • September 8, 2020
This study investigates the effect of microtubule stabilization on microcirculation reconstruction after spinal cord injury (SCI). The results showed that microtubule stabilization promotes angiogenes...
KEY FINDING: Microtubule stabilization promotes microcirculation reconstruction after SCI by increasing the number of microvessels, pericytes, and perfused microvessels.
Stem Cell Research & Therapy, 2021 • February 2, 2021
The study investigates the therapeutic potential of myogenic progenitor cells (MPCs) for muscle regeneration following ischemia/reperfusion injury (IRI) in a murine hindlimb model. Results showed that...
KEY FINDING: WIT-induced IRI in muscle requests increased numbers of injected MPC to engraft and persist, suggesting a possible rational for cell therapy to antagonize IRI.
Drug Discov Today Dis Models, 2007 • January 1, 2007
Mammals have a limited capacity for heart regeneration, unlike zebrafish. Zebrafish can regenerate heart tissue after injury, making them a valuable model for studying cardiac regeneration. Zebrafish ...
KEY FINDING: Zebrafish heart muscle can regenerate after injury with minimal scarring, replacing lost tissue with new contractile muscle.
Eur J Neurosci, 2009 • January 1, 2009
This study investigated whether a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) in a biodegradable implant could promote angiogenesis and formation of the blood-spinal cord b...
KEY FINDING: The coculture implant led to a four fold increase in functional vessels compared to the lesion control, implant alone, or implant plus NPCs groups.
J Neurosurg Spine, 2009 • October 1, 2009
This study examines surgical methods to reduce scar and cyst formation in complete transection SCI models in rats, focusing on the influence of vasculature disruption. Dural closure with sutures signi...
KEY FINDING: Dural closure using sutures resulted in significantly less glial scar formation compared to leaving the dura open.