Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 871-880 of 904 results
Journal of Biological Engineering, 2020 • November 5, 2020
This study was designed to develop hybrid fiber mat compose of Ch, PVA and silk through co-electrospining process to evaluate their synergic effect on wound healing process. The Ch-PVA + Silk hybrid f...
KEY FINDING: The Ch-PVA + Silk hybrid fiber prominently showed superior mechanical properties and desire swelling as well as hydrophilic microenvironment to those of pure PVA and Ch-PVA fibers.
Cell Death Discovery, 2020 • December 1, 2020
This study investigated the therapeutic effects of gelatine nanostructured lipid carriers (GNLs) encapsulating fibroblast growth factor 15 (FGF15) in a rat model of spinal cord injury (SCI). The resea...
KEY FINDING: FGF15-GNLs significantly improved hindlimb locomotor function in rats with SCI compared to FGF15 alone, as measured by the BBB locomotion scale.
Pharmaceutics, 2021 • December 26, 2020
This study aimed to develop lactoferrin-anchored tannylated mesoporous silica nanomaterials (LF/TA-MSNs) to enhance the osteo-differentiation ability of adipose-derived stem cells (ADSCs). The LF/TA-M...
KEY FINDING: LF/TA-MSNs demonstrated a prolonged release of lactoferrin (LF) for up to 28 days, indicating their potential for long-term drug delivery.
Bioengineering, 2021 • December 29, 2020
Electrospun fiber scaffolds mimic the native ECM in the nervous system and provide contact guidance for regenerating neurons. The major glia in the PNS and CNS are affected by several electrospun fibe...
KEY FINDING: Aligned electrospun fibers with a diameter of about 1 µm promote stem cell differentiation into Schwann cells and guide Schwann cell elongation and migration.
Theranostics, 2021 • January 1, 2021
This study explores the potential of a regenerative complex composed of a collagen/silk fibroin scaffold and human umbilical cord mesenchymal stem cells (hUCMSCs) to treat traumatic brain injury (TBI)...
KEY FINDING: The collagen/SF scaffold exhibited favorable physical properties, suitable degradation rate, and biocompatibility.
Stem Cell Research & Therapy, 2021 • January 25, 2021
This review discusses advances in combinatorial biomaterial scaffolds and MSC transplantation, targeting intercellular communications in the pathologic process following SCI. MSCs secrete various solu...
KEY FINDING: MSC transplantation promotes scaffold integration and regenerative growth potential, improving the healing process after SCI.
Scientific Reports, 2021 • January 11, 2021
This study aimed to assess whether UPAL gel implantation reduces inflammatory cytokine levels, prevents intervertebral disc degeneration, and reduces acute pain after discectomy in rat and rabbit disc...
KEY FINDING: UPAL gel implantation suppressed TNF-α and IL-6 production in both rat and rabbit models of discectomy.
Cells, 2021 • January 5, 2021
This study evaluated the effectiveness of biofunctionalized electroconducting microfibers (MFs) in promoting axon regeneration and modulating the immune response in a mouse model of spinal cord injury...
KEY FINDING: Functionalized microfibers (MFs) accelerated the sprouting of sensory axons after a partial unilateral dorsal quadrant lesion (PUDQL) in mice.
Bio-protocol, 2019 • October 5, 2019
The study presents a novel protocol for creating a 3D decellularized scaffold from bovine spinal cord ECM (3D-dCBS) for neural tissue engineering. The method involves preparing a viscous ECM-derived g...
KEY FINDING: The protocol effectively removes approximately 94.47% of nuclear material from the native bovine spinal cord.
Journal of Materials Science: Materials in Medicine, 2021 • March 22, 2021
This study investigates the potential of 3D-printed collagen/silk fibroin (3D-C/SF) scaffolds, designed to mimic the corticospinal tract, to promote functional recovery after complete spinal cord tran...
KEY FINDING: 3D-C/SF implants led to significant improvements in neurological function in rats compared to the C/SF group.