Implantation of regenerative complexes in traumatic brain injury canine models enhances the reconstruction of neural networks and motor function recovery

This study investigates a novel approach to treat traumatic brain injury (TBI) in a canine model by implanting a complex made of collagen/silk fibroin (SF) scaffold and human umbilical cord mesenchymal stem cells (hUCMSCs). The aim was to see if this complex could help repair the brain and improve motor function after a TBI. Researchers fabricated a porous scaffold from collagen and SF, tested its properties, and then combined it with hUCMSCs. This complex was then implanted into canines with TBI. The dogs were monitored using various methods such as MRI, electrophysiology, and gait analysis to assess brain integrity and motor skills. The study found that the complex had good biocompatibility and improved brain repair and motor function in the canines with TBI. This suggests that the complex could be a promising treatment for TBI in humans, offering a way to rebuild neural networks and restore movement.

• 1
  The collagen/SF scaffold exhibited favorable physical properties, suitable degradation rate, and biocompatibility.
• 2
  The group with complex implantation (collagen/SF scaffold combined with hUCMSCs) showed the best cerebral cortex integrity and motor functions compared to TBI alone, stem cells alone, or scaffold alone.
• 3
  The complex implantation led to increased regeneration of blood vessels and nerve fibers, reduced glial fibers, and decreased inflammatory factors in the injured brain tissue.