Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 881-890 of 904 results
Front. Bioeng. Biotechnol., 2021 • March 22, 2021
This study investigates the use of PLA nanofibers functionalized with SDF-1α/CXCL12 to enhance the migration of TEG3 cells, an OEC-derived cell line, for neural regeneration therapy. The results demons...
KEY FINDING: PLA nanofibers with a diameter of 950 nm showed the best results for TEG3 cell adhesion and migration.
Journal of Tissue Engineering, 2020 • November 21, 2020
This study investigates the combined effects of 7, 8-dihydroxyflavone (DHF) treatment and bone marrow-derived stem/stromal cells (BMSCs) engraftment into acellular nerve allografts (ANAs) for promotin...
KEY FINDING: 7, 8-DHF promotes the proliferation, survival, and Schwann-like cell differentiation of BMSCs in vitro by upregulating TrkB and ERK1/2 phosphorylation.
PNAS, 2002 • March 5, 2002
This study explores a novel approach to treating spinal cord injuries (SCI) by creating an implant that mimics the architecture of a healthy spinal cord. The implant consists of a polymer scaffold see...
KEY FINDING: Implantation of the scaffold-plus-cells promoted long-term improvement in function relative to a lesion-control group.
J Control Release, 2005 • June 2, 2005
This report, single lumen and multiple lumen conduits capable of controlled, sustained release of neurotrophic factors were fabricated, and have potential application in nerve regeneration. These cond...
KEY FINDING: The porosity and mechanical properties of the constructs were regulated by the ratio of porogen to polymer microsphere.
Eur Spine J, 2006 • November 15, 2005
This study assessed a new composite implant to induce regeneration of injured spinal cord in paraplegic rats following complete cord transection. Implants of adult human NOM cells were implanted into ...
KEY FINDING: Rats with complete spinal cord transection showed partial recovery of function after implantation with a composite implant containing either adult human nasal olfactory mucosa cells or human embryonic spinal cord cells.
The Journal of Neuroscience, 2008 • April 2, 2008
This study demonstrates that it is possible to inhibit glial scar formation and to facilitate regeneration after SCI using bioactive three-dimensional nanostructures displaying high densities of neuro...
KEY FINDING: Treatment with IKVAV PA after SCI reduced astrogliosis.
Neuron Glia Biol., 2007 • May 1, 2007
The study investigates the use of electrospun polydioxanone (PDS) matrices with aligned or random fibers to guide axonal regeneration after spinal cord injury. The directionality and growth dynamics o...
KEY FINDING: Electrospinning can produce matrices with aligned or randomly oriented fibers, confirmed by 2-D FFT analysis.
JOURNAL OF NEUROTRAUMA, 2008 • August 1, 2008
This study investigated the effects of varied implant architectures on spinal cord (SC) regeneration using 3D-printed scaffolds with five different macro-architectures: cylinder, tube, channel, open-p...
KEY FINDING: Open-path scaffold architectures enhanced spinal cord regeneration compared to the three other designs without the use of biological factors.
Eur J Neurosci, 2009 • January 1, 2009
This study investigated whether a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) in a biodegradable implant could promote angiogenesis and formation of the blood-spinal cord b...
KEY FINDING: The coculture implant led to a four fold increase in functional vessels compared to the lesion control, implant alone, or implant plus NPCs groups.
Biomaterials, 2009 • April 1, 2009
This study investigates surface immobilization to deliver complexed DNA (lipoplexes) from a multiple channel bridge in order to promote transgene expression in the injured spinal cord using low quanti...
KEY FINDING: Fibronectin, an ECM protein, produced greater gene expression levels and immobilization efficiencies compared with collagen and laminin.