Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 861-870 of 904 results
Cells, 2020 • September 17, 2020
This review highlights recent findings on the applications of HA-based materials in CNS regenerative medicine, emphasizing its impact on cell signaling and customizable properties. HA plays a signific...
KEY FINDING: HA influences cell migration, proliferation, differentiation, and other cell behaviors, playing a significant role in maintaining homeostasis in neuronal tissue.
Front. Cell Dev. Biol., 2020 • August 21, 2020
This study investigated the potential of local Taxol delivery via a self-assembling peptide scaffold (FGLmx/Taxol) to promote recovery after spinal cord injury (SCI). The results demonstrated that FGL...
KEY FINDING: Taxol released from the FGLmx/Taxol scaffold remained active and promoted neurite extension in vitro.
PNAS, 2020 • September 30, 2020
The study introduces an artificial carbon-nanotube based scaffold that, once implanted in SCI rats, improves motor function recovery. Confocal microscopy, MRI, and neurotracer labeling suggest that th...
KEY FINDING: CNF implants showed long-term bio-integration with limited tissue reactivity, invasion of neuronal fibers and blood vessels within the implant.
Polymers, 2020 • September 29, 2020
This study developed a collagen scaffold for glial scar replacement in a rat model of SCI, aiming to enhance axonal regeneration and neural plasticity. The collagen scaffold demonstrated excellent bio...
KEY FINDING: The collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning.
Acta Biomater., 2020 • November 1, 2020
This study investigates the impact of aligned PLLA microfibers on astrocyte reactivity following spinal cord injury (SCI), focusing on the modulation of neurotoxic (A1) and neuroprotective (A2) astroc...
KEY FINDING: PLLA fibers induce a mild neurotoxic phenotype in both naïve and A1 reactive astrocytes, indicating that the fibers alone may promote a detrimental environment.
Frontiers in Bioengineering and Biotechnology, 2020 • October 7, 2020
Spinal cord injury (SCI) leads to acute loss of motor and sensory function and has a dismal prognosis. Advancements in polymer-mediated approaches demonstrate promising treatment forms to remyelinate ...
KEY FINDING: SCI leads to loss of motor and sensory function and has a dismal prognosis, but polymer-mediated approaches show promise.
Polymers, 2020 • November 16, 2020
The research successfully manufactured highly porous, elastic PU/PLDL sponges suitable for filling gaps in injured spinal cords. The sponges' properties, including porosity and degradation rate, are t...
KEY FINDING: The porosity of the sponges decreased with the increase of polylactide content, influencing the mechanical properties.
International Journal of Nanomedicine, 2020 • January 1, 2020
The study investigated the interaction between MSCs and CP in a rat stroke model, finding that MSCs migrate to the CP and enhance its proliferation. MRI reveals MSC migration towards the CP in an isch...
KEY FINDING: ION-labeled MSCs migrate to the CP in an ischemic stroke model, as revealed by MRI and histological analysis.
Nano Res., 2021 • May 1, 2021
This review explores the bioengineering of nano metal-organic frameworks (nMOFs) for cancer immunotherapy, highlighting their potential to overcome limitations in current immunotherapy techniques. The...
KEY FINDING: nMOFs possess superior features over conventional nanocarriers, including high porosity, large surface area, greater tunability, accurate structure, and inherent superior functions without extra loading of functional agents.
Nanomedicine, 2021 • February 1, 2021
This study investigates the effect of RhoA knockdown by PgP/siRhoA nanoplexes on neuroinflammation and neuronal cell survival in a rat controlled cortical impact (CCI) TBI model in vivo. RhoA knockdow...
KEY FINDING: PgP/siRhoA nanoplexes efficiently knockdown RhoA expression in the injured brain tissue, both at the mRNA and protein levels.