Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 71-80 of 904 results
Journal of Orthopaedic Surgery and Research, 2025 • March 4, 2025
This study introduces a smart assistive bone-cement injection system for percutaneous vertebral augmentation (PVA) to overcome the shortcomings of currently used injection devices. The smart system de...
KEY FINDING: The motorized injection group had significantly fewer intraoperative X-ray fluoroscopies compared to the manual injection group, indicating reduced radiation exposure for the surgeon.
Science Advances, 2025 • March 26, 2025
This study engineered Mms6 mRNA-loaded LNPs for targeted delivery to macrophages and investigated whether these LNPs could promote locomotor functional recovery following SCI. Intravenous administrati...
KEY FINDING: Mms6 mRNA-LNPs improved anti-ferroptosis capabilities of macrophages via managing the balance of cellular iron metabolism in a hypoxic condition, which is common in SCI.
Bioelectronic Medicine, 2025 • March 6, 2025
The study investigated the effects of low-intensity trans-spinal focused ultrasound (tsFUS) on neuropathic pain in rats with chronic constriction injury (CCI). tsFUS was applied to the L5 spinal segme...
KEY FINDING: tsFUS treatment increased the von Frey threshold (vFT) in rats with CCI compared to sham treatment, indicating reduced mechanical sensitivity. This effect persisted for up to 23 days post-CCI.
Materials Today Bio, 2025 • March 4, 2025
The study investigates a combined approach using neural stem cell (NSC) microfibers and umbilical cord mesenchymal stem cell-derived exosomes (ucMSC-exos) to treat complete spinal cord injuries (SCI)....
KEY FINDING: ucMSC-exos can shift microglial polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype.
Biology of the Cell, 2025 • March 4, 2025
This study introduces a novel method, the fingerprint enhancement (FP-E) algorithm, for analyzing undergrowth collagen fibers, particularly in the context of spinal cord injury (SCI). The FP-E method ...
KEY FINDING: The fingerprint enhancement (FP-E) algorithm effectively detects and characterizes undergrowth collagen fibers in spinal cord injury samples.
TISSUE ENGINEERING: Part B, 2022 • March 14, 2022
This systematic review aimed to identify and evaluate animal models used to simulate spinal cord injury (SCI) for investigating biomaterial-mediated repair, following a predefined protocol. The study ...
KEY FINDING: The review identified well-documented mid-thoracic rat models with high SCI confirmation rates and survival, making them suitable for biomaterial-based therapy studies.
Bioactive Materials, 2022 • February 28, 2022
This study aimed to investigate the molecular mechanisms underlying the observed cell-specific effects of bioactive glasses (BGs) on giant cell tumor of bone-derived stromal cells (GCTSC) and bone mar...
KEY FINDING: BG treatment leads to a significant decrease of cell viability in tumor cells but not in bone marrow cells.
Drug Delivery, 2022 • January 1, 2022
This study successfully synthesized chitosan-modified hollow manganese dioxide nanoparticles (CM) to deliver resveratrol (Res) for spinal cord injury (SCI) treatment. In vitro and in vivo experiments ...
KEY FINDING: Chitosan modification enables HM to cross the blood–spinal cord barrier (BSCB) and deliver Res to the injury site.
Materials Today Bio, 2022 • September 2, 2022
The review summarizes the progress made in the applications of GSNO in anti-infective biomaterials. It mainly includes the biological properties of GSNO and its application in biomaterials and provid...
KEY FINDING: GSNO possesses antibacterial activity influenced by factors like bacterial strain, dose, treatment duration, and NO release kinetics. Studies have evaluated GSNO's antibacterial properties in pulmonary, cutaneous, and other infections.
Acta Biomater., 2022 • October 15, 2022
The BEACON system developed herein eliminates the need to target a cell or tissue receptor by targeting an implantable biomaterial with location-controllable accumulation and sustained presentation ov...
KEY FINDING: Demonstrated temporal dexterity in NP administration by injecting 6 days post-SCI.