Biomedical Research

KEY FINDING: China and the United States are the leading countries in nanotechnology research for SCI, with China showing rapid growth in publications after 2019.

KEY FINDING: EJCDs promote HSC self-renewal and erythroid differentiation in the bone marrow by upregulating FZD4 protein expression in LSK cells.

KEY FINDING: Apelin-13 is significantly downregulated in the injured sites of the SCI model rats since day 14 after modeling.

KEY FINDING: LNT-UsSeNPs exhibit superior ROS scavenging capabilities compared to conventional LNT-SeNPs, protecting PC-12 cells from oxidative stress-induced cytotoxicity and alleviating mitochondrial dysfunction.

KEY FINDING: CTGF was found to be the most effective growth factor for inducing the differentiation of UCMSCs into tendon cells, leading to changes in cell morphology and increased expression of tendon-specific proteins.

KEY FINDING: The OPDL gel demonstrated excellent injectability and self-healing properties, allowing its precise application at the site of spinal cord injury by using a syringe for effective care delivery.

KEY FINDING: Subthreshold microcoil stimulation depolarized node membranes, enhancing activation and restoring axonal conductance in demyelinated regions.

KEY FINDING: Lipid nanovesicles, including liposomes and extracellular vesicles, can be modified to enhance their ability to target specific cells and tissues in the spinal cord.

KEY FINDING: NABDM modifies the polarization direction of microglia in vitro, and promotes the differentiation of NSCs by activating the cGMP–PKG and cAMP signaling pathways.

KEY FINDING: Oligo-L treatment significantly improved neuropathic pain and motor function performance in rats with SCI from the first week post-injury.