Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 81-90 of 904 results
Materials Today Bio, 2022 • August 19, 2022
PEEK's stable chemical and physical properties, excellent X-ray transmittance, and bone-like mechanical properties make it suitable for orthopedic implants. However, its biological inertness leads to ...
KEY FINDING: Surface modification of PEEK, including bioactive material coating, chemical treatment, and physical treatment, enhances bioactivity, allowing easier integration with native bone tissue.
J Vis Exp, null • February 23, 2023
The Evoked Potential Operant Conditioning System (EPOCS) aids scientific investigation of sensorimotor function, and can administer targeted neurobehavioral training that can impact sensorimotor rehab...
KEY FINDING: EPOCS can be used to down-condition the Hoffmann reflex in the soleus muscle, which can improve walking in people with spastic gait due to incomplete spinal-cord injury.
Frontiers in Bioengineering and Biotechnology, 2022 • September 15, 2022
The study successfully fabricated FA-PEG/ZIF-8 nanoparticles, demonstrating their potential to restore function in vivo by selectively eliminating pro-inflammatory microglia/macrophages (M/Ms) without...
KEY FINDING: FA-PEG/ZIF-8 treatment significantly eliminated pro-inflammatory M/Ms in vivo without targeting other nerve cells and downregulated inflammation in the injured lesion.
Materials Today Bio, 2022 • September 16, 2022
This study introduces a novel sEVs-NGL/T hydrogel for treating spinal cord injury (SCI). The hydrogel combines tannic acid's antioxidant properties with the therapeutic potential of mesenchymal stem c...
KEY FINDING: The sEVs-NGL/T hydrogel exhibited excellent antioxidant properties in vitro, effectively scavenging DPPH radicals and reducing H2O2 levels.
Journal of Nanobiotechnology, 2024 • July 3, 2024
This study investigates the therapeutic effects of iPSC-NSCs-Exos on microglia/macrophage pyroptosis in a mouse SCI model, utilizing miRNA microarray analysis and rescue experiments to confirm the rol...
KEY FINDING: IPSC-NSCs-derived exosomes can package and deliver let-7b-5p, regulating the expression of LRIG3 to ameliorate microglia/macrophage pyroptosis and enhance motor function in mice after SCI.
Bioengineering, 2022 • October 9, 2022
The study investigates the therapeutic potential of human amniotic epithelial cell (hAEC)-derived neural-like cells delivered via a 3D-printed biomimetic scaffold for spinal cord injury (SCI) treatmen...
KEY FINDING: Human amniotic epithelial cells (hAECs) can be effectively induced into neural-like cells using a compound cocktail (BGVB), showing morphological changes and expression of neural cell markers.
Frontiers in Pharmacology, 2022 • October 5, 2022
The study analyzed peripheral blood RNA-seq samples from SCI patients and healthy controls to identify key differentially expressed genes and construct a diagnostic model. In vitro experiments demonst...
KEY FINDING: Peripheral blood transcriptome is altered after SCI, reflecting similar negative effects as neuronal damage at the lesion site.
Biomedicines, 2022 • October 8, 2022
This study evaluates the efficacy of an antibiotic-loaded ceramic-based bone graft substitute (HACaS+G) for treating infected non-unions in a rat model. The results indicate that HACaS+G is osteoinduc...
KEY FINDING: HACaS+G demonstrated osteoinductive properties, stimulating bone formation in both infected and non-infected conditions.
BMC Musculoskeletal Disorders, 2022 • October 14, 2022
This study evaluates the mechanical strength of six different dual antibiotic-loaded bone cement (dALBC) preparations made from three commonly used PMMA bone cements (Copal spacem, Copal G + V, Palaco...
KEY FINDING: Copal G + V showed the highest bending strength after 24 hours, but after six weeks, the bending strength decreased in all preparations.
Bioengineering, 2024 • July 31, 2024
This study explores the use of aligned nanofiber scaffolds derived from porcine decellularized spinal cord matrix (DSC) to enhance mesenchymal stem cell (MSC)-based treatments for spinal cord injury (...
KEY FINDING: The decellularization method effectively removed 87% of the immune components from the porcine spinal cord while retaining crucial proteins beneficial for nerve regeneration.