Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 671-680 of 904 results
Macromolecular Bioscience, 2024 • September 30, 2024
The review highlights the increasing incidence of nerve tissue injuries and neurodegenerative diseases and the limitations of current treatments. It discusses the potential of neural tissue engineerin...
KEY FINDING: Biomaterials can enhance neurogenesis and differentiation of stem cells. Fibrous scaffolds and hydrogels have shown promise in promoting nerve cell proliferation and reducing inflammation.
Journal of Nanobiotechnology, 2024 • October 9, 2024
This study designed and synthesized curcumin nanoparticles (HA-CurNPs) with excellent biocompatibility for effective treatment of SCI. HA-CurNPs exhibit better antioxidant performance compared to both...
KEY FINDING: HA-CurNPs effectively protect neuronal cells and myelin, reduce glial scar formation, thereby facilitating the repair of damaged spinal cord tissues, restoring electrical signaling at the injury site, and improving motor functions.
Stem Cell Research & Therapy, 2024 • October 14, 2024
The combination of LOCAS and iPSCs-NSCs demonstrated a positive therapeutic impact on motor function recovery and tissue repair in rats with SCI. LOCAS combined with iPSCs-NSCs showed a good therapeut...
KEY FINDING: After 12 weeks, rats in the LOCAS-iPSCs-NSCs group exhibited significantly higher BBB scores (8.6) compared to the LOCAS-iPSCs-NSCs group (5.6) and the Model group (4.2).
International Journal of Nanomedicine, 2024 • October 19, 2024
In this study, we innovatively constructed a nanocomplex to achieve more effective repair after spinal cord injury. Through in vitro and in vivo experiments, we found that this biomaterial can effecti...
KEY FINDING: Achieving nerve growth factors sustained release, GMNF had good biocompatibility and could effectively penetrate into the cells with good targeting permeability.
International Journal of Surgery, 2024 • November 5, 2024
Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. Stem cells’ regenerat...
KEY FINDING: Stem cell therapy offers unprecedented potential to address a wide range of debilitating diseases and injuries.
Int. J. Mol. Sci., 2024 • October 29, 2024
The study explores the potential of PLA/PCL polymer patches as a therapeutic tool for myelomeningocele (MMC) treatment. The patches are designed to deliver Noggin, a BMP inhibitor, to mitigate BMP-ind...
KEY FINDING: PLA/PCL patches are biocompatible with neural progenitor cells (NPCs), supporting their culture without altering cell morphology or fate.
Bioeng Transl Med, 2024 • May 1, 2024
The study developed injectable hydrogels for local, controlled release of protein therapeutics into tissue. The hydrogel, featuring slowly hydrolyzing linkers, prolongs the therapeutic effect, minimiz...
KEY FINDING: Anti-CD47 monoclonal antibodies incorporated into subsurface-injected hydrogel solutions exhibited cytotoxic activity against infiltrative high-grade glioma xenografts in the rodent brain.
Advanced Science, 2025 • November 25, 2024
This study introduces a novel COCu-Tac-iNSCs transplantation system to address challenges in cell-based therapies for spinal cord injury, such as graft rejection and mitochondrial dysfunction. The sel...
KEY FINDING: The COCu-Tac hydrogel promotes the survival and neuronal differentiation of transplanted iNSCs without systemic immunosuppression, leading to improved outcomes compared to iNSCs alone.
Molecules, 2024 • November 14, 2024
This study aimed to develop and characterize three-dimensional chitosan-based cellular scaffolds for nervous tissue regeneration, utilizing chitosan, l-Aspartic acid, l-Glutamic acid, propylene glycol...
KEY FINDING: The addition of poly(dopamine) and CBD significantly impacted the scaffolds’ swelling properties and structural stability.
Military Medical Research, 2024 • January 1, 2024
This review focuses on the mechanisms through which BAPPs influence the microenvironment for tissue repair via reactive oxygen species, blood and lymphatic vessels, immune cells, and repair cells. A v...
KEY FINDING: BAPPs modulate the tissue microenvironment by influencing reactive oxygen species (ROS), blood and lymphatic vessels, immune cells, and repair cells, creating a customizable approach to tissue regeneration at specific anatomical sites.