Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 681-690 of 904 results
Front. Bioeng. Biotechnol., 2024 • November 21, 2024
This study constructs a Dual-Phase SilMA hydrogel scaffold (DPSH), incorporating PLGA microspheres encapsulating neurotrophin-3 (NT-3) and angiotensin (Ang-(1–7), and neural stem cells. In vitro studi...
KEY FINDING: Ang-(1–7) significantly induced M2 microglia polarization by 1.8-fold (p < 0.0001), effectively reducing inflammation.
Advanced Healthcare Materials, 2025 • December 12, 2024
The study evaluated an rGO-based nanocomposite supported by adipose decellularized ECM for spinal cord injury repair. The nanocomposite evoked a tissue-regenerative response, demonstrating the potenti...
KEY FINDING: adECM-rGO nanocomposites completely restored the integrity of the spinal cord after hemisection SCI in rats.
ACS Nano, 2025 • December 21, 2024
This study investigates the role of neutrophil membrane vesicles (NMVs) in modulating the inflammatory response after spinal cord injury (SCI) and promoting nerve regeneration. A biomimetic "Trojan ho...
KEY FINDING: NMVs exhibit an "efferocytosis-like" effect, being endocytosed by macrophages and reprogramming them to a pro-regenerative phenotype by influencing glutamine metabolism and oxidative phosphorylation.
Front. Bioeng. Biotechnol., 2024 • December 16, 2024
This study investigates the use of co-cultured neural stem cells (NSCs) and bone mesenchymal stem cells (BMSCs) within a low-modulus GelMA hydrogel scaffold to enhance spinal cord injury (SCI) repair....
KEY FINDING: Low-modulus GelMA hydrogels promote cell migration, viability, and proliferation of co-cultured NSCs and BMSCs in vitro.
Materials Today Bio, 2025 • December 6, 2024
This research presents a novel hydrogel system that responds to both hyaluronidase and external magnetic stimuli, designed for spinal cord injury (SCI) repair. The hydrogel, loaded with NGF and Fe3O4 ...
KEY FINDING: The novel hydrogel significantly promoted neural axon growth and development under an external magnetic field in cellular experiments.
Bioactive Materials, 2025 • December 6, 2024
This study presents a bioinspired conductive oriented nanofiber felt designed to treat complete spinal cord injury (SCI) by promoting neural regeneration and suppressing inflammation. The nanofiber fe...
KEY FINDING: The nanofiber felt promotes M2 macrophage polarization, reducing inflammation and oxidative stress.
Advanced Science, 2025 • January 9, 2025
The study introduces a SETLSA strategy for spinal cord injury (SCI) treatment based on cerium (Ce)-doped upconversion antioxidant nanoenzymes (Ce@UCNP-BCH). These nanoenzymes eliminate reactive oxygen...
KEY FINDING: Ce@UCNP-BCH effectively facilitates the regeneration of spinal cord including myelin sheath, and promotes the functional recovery of SCI mice.
Advanced Science, 2025 • January 10, 2025
This study introduces a single-component hydrogel based on the recombinant protein CsgA, enhanced with the GHK peptide, for spinal cord injury (SCI) repair. The hydrogel's formation relies on the phys...
KEY FINDING: CsgA-GHK hydrogel modulates microglial M2 polarization in vitro, indicating an anti-inflammatory effect.
Journal of Translational Medicine, 2025 • January 8, 2025
The study identifies key biomarkers related to ferroptosis and the immune microenvironment after SCI, providing clues for subsequent studies at the transcriptional and single-cell levels. WGCNA identi...
KEY FINDING: A novel subcluster of microglia exhibiting M1 polarization and a ferroptosis phenotype is involved in SCI, potentially triggering neuroinflammation and neuronal degeneration.
Journal of Nanobiotechnology, 2025 • January 7, 2025
This study developed a Lightgel/NGF/CeMn NP-PEG composite material that promotes neuronal repair and regeneration, enhances the immune microenvironment post-SCI, and demonstrates remarkable therapeuti...
KEY FINDING: The Lightgel/NGF/CeMn NP-PEG composite effectively eliminates ROS, promoting M2 macrophage polarization. It also reduces pro-inflammatory cytokines, and supports neuronal regeneration in SCI rats.