Biomedical Research

KEY FINDING: Mn-ZIF nanozymes possess peroxidase (POD) activity, enabling them to oxidize tumor-localized H2O2 into hydroxyl radicals (·OH), effectively killing tumor cells.

KEY FINDING: Intranasally-delivered sEVs entered the central nervous system and were extensively taken up by spinal neurons and some microglia.

KEY FINDING: bFGF-loaded GelMA microspheres significantly promoted the proliferation and differentiation of neural stem cells in vitro.

KEY FINDING: Recent advances in bioengineering have shown that therapies based on cells, biomaterials, and biomolecules are effective in spinal cord regeneration.

KEY FINDING: 3D-C/C scaffold implantation leads to improving the locomotor function in SCI rat.

KEY FINDING: The hydrogel exhibits mechanical properties comparable to human soft tissues, such as skeletal muscle, suggesting its suitability for tissue engineering applications.

KEY FINDING: COL-HEP/GF scaffolds induce a tight but subtle control over cell signaling and extracellular matrix organization.

KEY FINDING: 3D bioprinting enables the precise creation of scaffolds mimicking the spinal cord's structure, with the ability to embed living cells directly, promoting their survival and integration.

KEY FINDING: The Exo-dECM hydrogel exhibited robust mechanical stability and excellent cytocompatibility, allowing effective injection into the injury site to fill the lesion cavity.

KEY FINDING: SCMECs promote axon outgrowth in a non-contact fashion by downregulating miR-323-5p expression in neurons.