Biomedical Research

KEY FINDING: Ligand-screened cerium-based MOFs with creatine loading and polydopamine encapsulation (Gel-Cr/Ce@PDA) regulate macrophage phenotypes towards M2 via metabolic reprogramming.

KEY FINDING: The pCel nanoplatform exhibits high ROS scavenging activity and promotes the polarization of M1 macrophages toward the M2 phenotype in vitro.

KEY FINDING: The PF-OMSF@JK composite hydrogel significantly improves in vivo SCI regeneration in Sprague–Dawley rats through a reduction in inflammation and neuronal differentiation of the incorporated stem cells.

KEY FINDING: HA-bFGF hydrogel had no toxicity to the organs of rats and was relatively safe, indicating a higher level of biocompatibility.

KEY FINDING: Glial fibrosis and fluid-filled cysts impede electrical signaling and stimulus conduction in spinal cord tissue, hindering neural regeneration.

KEY FINDING: SHIELD with the RGDS ligand demonstrated the highest cell viability and the most robust neurite outgrowth in vitro.

KEY FINDING: LMGDNPs showed a delayed release of lactate oxidase (LOX) and effectively consumed lactate, a harmful metabolic byproduct, creating a more favorable environment for cells.

KEY FINDING: MnO2@TMNP effectively binds inflammatory factors and nerve growth factors, inhibiting inflammation-induced apoptosis and nerve ingrowth.

KEY FINDING: Graphene-based nanocarriers did not show cell toxicity and enhanced bone marrow derived mesenchymal stem cell (BM-MSC) proliferation by approximately 10% after 48 hours.

KEY FINDING: hADSC-Exos promote neurogenesis in brain organoid and ameliorate social deficits in ASD mouse model BTBR T + tf/J (BTBR).