Modified FGF Hydrogel for Effective Axon Formation by Enhanced Regeneration of Myelin Sheath of Schwann Cells Using Rat Model

International Journal of Nanomedicine, 2023 · DOI: https://doi.org/10.2147/IJN.S417723 · Published: December 5, 2023

Simple Explanation

This study introduces a new hydrogel, HA-bFGF, designed to help repair spinal cord injuries. The hydrogel contains a growth factor (bFGF) and is made to be injected directly into the injured area to promote healing. The researchers tested the hydrogel on rats with spinal cord injuries and found that it helped to reduce inflammation and promote the regrowth of nerve fibers. It also improved the function of Schwann cells, which are important for nerve insulation. The findings suggest that this HA-bFGF hydrogel could be a promising new treatment for spinal cord injuries, helping to restore nerve function and improve patient outcomes.

Study Duration

4 Weeks

Participants

Adult female Sprague-Dawley rats (200–250 g)

Evidence Level

Level 2: Animal Model Study

Key Findings

1
HA-bFGF hydrogel had no toxicity to the organs of rats and was relatively safe, indicating a higher level of biocompatibility.
2
HA-bFGF markedly reduced the levels of inflammation-related biomarkers in SCI tissues.
3
Treatment with HA-bFGF promoted spinal cord regeneration, axon regeneration across the scar boundary, and enhanced the recovery of neurological function after an SCI.

Research Summary

The study synthesized a novel injectable hydrogel containing bFGF (HA-bFGF) and proved it had superior biocompatibility. HA-bFGF assisted with the regeneration of myelin sheath after an SCI. HA-bFGF could promote the myelin re-sheath of Schwann cells, reduce the production and infiltration of microglia and astroglia, and promote axon regeneration by neuronal cells in treatment of an SCI.

Practical Implications

Therapeutic Potential

HA-bFGF hydrogel shows promise as a therapeutic strategy for repairing spinal cord injuries by promoting axon regeneration and reducing inflammation.

Drug Delivery

The controlled in situ delivery of HA-bFGF allows for targeted treatment and improved outcomes for SCI patients.

Biocompatibility

The hydrogel's demonstrated biocompatibility suggests it is safe for in vivo applications and reduces the risk of adverse effects.

Study Limitations

1
The main loading material is HA, which is relatively expensive and may be an economic consideration for patients.
2
Schwann cells mainly grow in the peripheral nervous system, and although their numbers are small, they also function in the spinal cord. Therefore, it is necessary to further explore the mechanism of action of Schwann cells in the spinal cord in follow-up studies.
3
On the other hand, we used bFGF in the hydrogel for regeneration of myelin sheath, and this is a promising technique for improving repair at a spinal cord injury site.

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