Exosome lncRNA IFNG‑AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD‑like behavior in BTBR mice

This study explores the potential of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) as a treatment for autism spectrum disorder (ASD). These exosomes contain long non-coding RNAs (lncRNAs) that may promote neurogenesis. The research identifies a specific lncRNA, IFNG-AS1, within these exosomes that acts as a molecular sponge, regulating the miR-21a-3p/PI3K/AKT signaling pathway, which is crucial for brain development and function. By transplanting these hADSC-Exos into a mouse model of ASD, the study found improvements in neurogenesis and a reduction in ASD-like behaviors, suggesting a potential therapeutic avenue for individuals with ASD.

• 1
  hADSC-Exos promote neurogenesis in brain organoid and ameliorate social deficits in ASD mouse model BTBR T + tf/J (BTBR).
• 2
  Fluorescence in situ hybridization (FISH) confirmed lncRNA Ifngas1 significantly increased in the prefrontal cortex (PFC) of adult mice after hADSC-Exos intraventricular injection.
• 3
  The lncRNA Ifngas1 can act as a molecular sponge for miR-21a-3p to play a regulatory role and promote neurogenesis through the miR-21a-3p/PI3K/AKT axis.