Biomedical Research

KEY FINDING: Sema3A is expressed by NSCs and its expression increases after transplantation into the injured spinal cord.

KEY FINDING: Transplantation of the 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes promoted peripheral nerve regeneration and restoration of motor function, similar to autograft transplantation.

KEY FINDING: Spinal cord organoids dynamically simulate neural tube formation and exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal axes.

KEY FINDING: The HES rapidly expanded 80-fold in size upon absorbing 2.6 million hAESCs within 2 minutes, representing over a 400% increase in loading capacity versus controls.

KEY FINDING: Electrode shape has little effect on the induced electric field distribution within the spinal cord.

KEY FINDING: Microfibrils redistribute the electric field, focusing it in the spaces between the fibers, allowing the field to pass through. With a 10V voltage, the field can reach up to 100 kV/m.

KEY FINDING: Natural hydrogels are efficient scaffolds for functional recovery and drug/cell delivery after SCI.

KEY FINDING: EF-sEVs promote functional behavioral recovery after SCI in rats, improving hindlimb movement and coordination.

KEY FINDING: Pericyte-derived exosomes enhance endothelial cell barrier integrity in vitro.

KEY FINDING: The combination of collagen fibers and rGO with alginates increased cell viability and the gene expression of collagen-binding receptor subunits such as integrin α1, and β1.