Ligand-Screened Cerium-Based MOF Microcapsules Promote Nerve Regeneration via Mitochondrial Energy Supply

This study introduces microcapsules (Cr/Ce@PDA nanoparticles) that combine ROS scavenging and energy supplementation to reverse energy deficits in macrophages and neuronal cells. The microcapsules reprogram inflammatory macrophages to the proregenerative phenotype and promote regeneration and differentiation of neural cells. In vivo experiments confirm the effect of the microcapsules in regulating early ROS-inflammation positive-feedback chain reactions and continuously promoting nerve regeneration.

• 1
  Ligand-screened cerium-based MOFs with creatine loading and polydopamine encapsulation (Gel-Cr/Ce@PDA) regulate macrophage phenotypes towards M2 via metabolic reprogramming.
• 2
  The M2 macrophages release cytokines that form an anti-inflammatory microenvironment, promoting neural stem cell (NSC) differentiation into neuronal cells.
• 3
  The microcapsules provide a long-term energy supply, accelerating axonal regeneration and improving locomotor and urinary function recovery in SCI rats.