Pericyte‑derived exosomal miR‑210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway

Journal of Nanobiotechnology, 2023 · DOI: https://doi.org/10.1186/s12951-023-02110-y · Published: September 15, 2023

Simple Explanation

This study investigates how pericytes, cells that support blood vessels, can help repair damage after a spinal cord injury (SCI). The focus is on exosomes, tiny vesicles released by pericytes, and their role in improving the function of blood vessels in the injured spinal cord. The study found that exosomes released by pericytes contain a specific molecule called miR-210-5p. This molecule appears to improve the function of mitochondria (the cell's power plants) and reduce lipid peroxidation (a type of cell damage) in the blood vessels of the spinal cord. The researchers suggest that miR-210-5p works by activating a specific signaling pathway (JAK1/STAT3), which helps restore the barrier function of blood vessels in the spinal cord. This could potentially lead to new treatments for SCI.

Study Duration

Not specified

Participants

Mice

Evidence Level

Not specified

Key Findings

1
Pericyte-derived exosomes enhance endothelial cell barrier integrity in vitro.
2
Pericyte-derived exosomes promote the recovery of motor function and protect the BSCB in mice after SCI.
3
Exosomal miR-210-5p regulates lipid peroxidation in target cells via the miR-210/JAK1/STAT3 axis and improve mitochondrial function.

Research Summary

This study investigates the paracrine influence of pericytes on endothelial cells following SCI considering the unique association between these two cell types. Our study demonstrated that exosomal miR-210 inhibits lipid peroxidation and protects mitochondrial function in the vascular endothelial cells of the spinal cord following injury. This finding may further contribute to our understanding of the intricate interplay between pericytes and endothelial cells following SCI, and provide a potential therapeutic target for SCI.

Practical Implications

Therapeutic Target for SCI

The discovery of miR-210-5p's role in restoring the blood-spinal cord barrier presents a novel therapeutic target for SCI.

Exosome-based Therapies

Pericyte-derived exosomes, enriched with miR-210-5p, may be developed as a therapeutic agent to promote vascular repair and functional recovery after SCI.

Understanding Cell Interactions

This study enhances our understanding of the interplay between pericytes and endothelial cells in the context of SCI, which can guide the development of targeted therapies.

Study Limitations

1
The precise mechanisms by which miR-210-5p regulates JAK1/STAT3 signaling require further investigation.
2
The long-term effects of exosome-based therapy on SCI recovery need to be evaluated.
3
The study is primarily focused on in vitro and in vivo models; clinical trials are needed to validate the findings in human patients.

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