Biomedical Research

KEY FINDING: PLGA-miR+Sp and PLGA-miR+PEI formulations were found to be significant in their immunomodulatory effects compared to naked PLGA-based NPs.

KEY FINDING: Decellularized spinal cord ECM (dECM) can be processed into electrospun fiber scaffolds while maintaining essential ECM components and removing cellular material.

KEY FINDING: Myelotomy and lesion debridement alone did not cause further neural damage compared to SCI alone, but had little positive effect on neural regrowth.

KEY FINDING: Bioactive hydrogels incorporating biological components such as DNA, proteins, and peptides exhibit unique biological properties beneficial for SCI repair.

KEY FINDING: The NGP hydrogel exhibits suitable pore size, good biocompatibility, excellent conductivity, and injectable and self-repairing properties.

KEY FINDING: SCMECs and BMECs exhibit distinct gene and protein expression profiles related to angiogenesis, immunity, and metabolism.

KEY FINDING: Chitosan (CHI) does not promote neuronal maturation but allows for the development of astrocytes, suggesting a preference for glial cell development over neuronal development.

KEY FINDING: The release rate of payloads from the hydrogels can be customized by selecting azidoacids of varying lengths, thereby controlling ester hydrophobicity.

KEY FINDING: The addition of both SDS and HYDROSAP led to the formation of tiny, fibrous, and uniform nanofibers without beads-on-string morphology and with a very narrow diameter distribution between 100–300 nm.

KEY FINDING: miR-26a@SPIONs-OECs, when stimulated by a magnetic field, release extracellular vesicles rich in miR-26a, which inhibits PTEN and GSK-3β signaling pathways in neurons, promoting axon growth.