Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 281-290 of 904 results
Frontiers in Bioengineering and Biotechnology, 2023 • February 2, 2023
This study investigated the effects of combined cervical transcutaneous and lumbosacral epidural stimulation on voluntary control of stepping in individuals with chronic motor complete spinal cord inj...
KEY FINDING: Cervical transcutaneous stimulation (scTS) suppressed the amplitude of motor evoked potentials induced by lumbosacral epidural stimulation (scES) in most lower-extremity muscles.
Journal of NeuroEngineering and Rehabilitation, 2023 • January 1, 2023
The Mobile Robotic Balance Assistant (MRBA) is a novel device combining gait assistance and wheelchair functionalities for home and community use. MRBA uses a pelvic interface to support users during ...
KEY FINDING: Healthy subjects walking with MRBA exhibited a lower speed, smaller step length, and longer step time compared to free walking.
Frontiers in Bioengineering and Biotechnology, 2023 • February 27, 2023
This study analyzes publications on electroactive materials for spinal cord injury from 2012 to 2022, finding a growing interest in the field. The research identifies the United States and China as ma...
KEY FINDING: The number of publications and average annual citation rate in the field are increasing.
IEEE J Biomed Health Inform., 2023 • March 1, 2023
This study introduces a novel CMAP scan analysis method using staircase function fitting to extract MUNE and other physiological information. The staircase fitting model was validated using simulated ...
KEY FINDING: The staircase function fitting provides an appropriate approach to CMAP scan processing, yielding MUNE and other useful parameters for examination of motor unit loss and muscle fiber reinnervation.
Front. Bioeng. Biotechnol., 2023 • March 13, 2023
Spinal cord injury (SCI) leads to sensory and motor dysfunction, with limited treatment options. Cell therapy shows promise but faces challenges. Exosomes, as paracrine factors released by cells, have...
KEY FINDING: Stem cell-derived exosomes have anti-inflammatory effects and can play a role in SCI treatment.
IEEE Trans Neural Syst Rehabil Eng, 2023 • June 8, 2023
This study developed a data-driven trajectory optimization method for reaching motions that accounts for person-specific muscle weakness and loss of function in individuals with SCI. The method involv...
KEY FINDING: Trajectory optimization improved the ability to reach targets compared to naive direct-to-target paths.
Sci. Adv., 2025 • April 2, 2025
This study engineered mesenchymal stem cell-derived extracellular vesicles (EVs) to enhance their therapeutic efficacy for spinal cord injury (SCI) treatment. The EVs were reinforced with pro-angiogen...
KEY FINDING: The study successfully created a hydrogel that releases EVs in response to ROS, allowing for on-demand regulation of SCI treatment.
Int. J. Mol. Sci., 2022 • December 28, 2021
This study aimed to enhance rhBMP-2-mediated regeneration of critical sized segmental bone defects using a biomimetic silk fibroin scaffold. The scaffold was designed with anisotropic channel-like por...
KEY FINDING: Highly porous, anisotropic silk scaffolds were successfully produced and demonstrated good cytocompatibility in vitro.
Frontiers in Pharmacology, 2024 • June 27, 2024
This review discusses the use of hydrogels combined with neural stem cells (NSCs) for spinal cord injury (SCI) regeneration. It highlights the limitations of endogenous regeneration and the potential ...
KEY FINDING: NSCs secrete active compounds that promote nerve tissue regeneration, improve nerve cell survival, neuroplasticity, and neuroimmune modulation.
Journal of NeuroEngineering and Rehabilitation, 2010 • May 21, 2010
This study introduces and evaluates a novel mechanomyogram (MMG)-driven switch controlled by small eyebrow movements for computer access, especially targeting individuals with severe physical disabili...
KEY FINDING: The MMG-driven switch achieved an average sensitivity of 99.7 ± 0.4% and specificity of 99.9 ± 0.1%.