Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 291-300 of 904 results
Bioactive Materials, 2023 • January 1, 2023
This study synthesized layered double hydroxide (LDH) nanoparticles and optimized their ion elemental compositions to promote chondrogenic differentiation of human umbilical cord mesenchymal stem cell...
KEY FINDING: LDH nanoparticles with specific ion compositions (MgFe–NO3) effectively promoted chondrogenic differentiation of hUC-MSCs.
Int. J. Mol. Sci., 2024 • December 11, 2024
Nanotechnology has emerged as a transformative force in neuroscience, addressing challenges that have long impeded progress in the diagnosis and treatment of CNS disorders. Theranostic NPs stand out a...
KEY FINDING: Nanoparticles can be engineered to cross the blood-brain barrier (BBB) using passive targeting, active targeting, and stimuli-responsive systems, enhancing drug delivery to the CNS.
ACS Nano, 2025 • January 22, 2025
This study introduces a novel method using a chiral nanofiber-based extracellular matrix (ECM) to metabolically reprogram neural stem cells (NSCs) for spinal cord injury (SCI) treatment. The dextral n...
KEY FINDING: Dextral hydrogel (DH) promotes neural differentiation of NSCs and improves neural regeneration in rat SCI models by regulating fatty acid metabolism of NSCs.
Acta Biomater, 2015 • December 1, 2015
The study combined cell transplantation, neurotrophic factor delivery, and anti-inhibitory molecule delivery in fibrin scaffolds to treat spinal cord injury (SCI). The aim was to improve recovery by r...
KEY FINDING: pMN survival was not affected by the combination therapy with AIMS in vitro.
Frontiers in Neuroscience, 2015 • September 2, 2015
This study investigates the functionalization of nanoparticles (NPs) with nerve growth factor (NGF) and glial cell-line derived neurotrophic factor (GDNF) to support regeneration in the nervous system...
KEY FINDING: Covalent binding of NGF to PEI-NPs impaired its bio-functionality, while non-covalent binding successfully differentiated PC12 cells.
Journal of Visualized Experiments, 2016 • April 5, 2016
The study presents two surgical approaches to bridge tissue gaps in the spinal cord: (1) acute complete transection and mMS implantation, and (2) chronic spinal cord lesion, fibrous scar removal, and ...
KEY FINDING: The microconnector system (mMS) stabilized the completely transected spinal cord stumps and decreased shrinkage of the tissue.
Medical Science Monitor, 2015 • October 21, 2015
The study introduces a novel strategy for precise nanoparticle delivery into syringomyelic cysts using MRI guidance in a rat model of spinal cord injury. The method involves using MRI images to calcul...
KEY FINDING: The study successfully developed a method for precise, MRI-guided delivery of nanoparticles into syringomyelic cysts in rats with spinal cord injuries.
TISSUE ENGINEERING: Part A, 2021 • March 8, 2021
This study investigated the use of micro-TENNs in a rodent model of SCI, using a minimally invasive model of SCI utilizing an epidural embolectomy balloon catheter to cause mechanical compression. The...
KEY FINDING: Graft DRG axons survived at 1 week post-implantation within the hydrogel encasement.
Neural Regeneration Research, 2021 • September 1, 2021
This study fabricated a conductive graphene oxide composited chitosan scaffold and transplanted it into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold ...
KEY FINDING: The chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue.
Bioactive Materials, 2021 • January 24, 2021
The study introduces a novel therapeutic approach for spinal cord injury (SCI) using a bioactive, injectable, self-healing, and anti-inflammatory hydrogel (FE@EVs) designed for the sustained release o...
KEY FINDING: The FE@EVs hydrogel effectively encapsulates and releases extracellular vesicles in the injured spinal cord, facilitating efficient integrated regulation.