Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 131-140 of 904 results
Materials Today Bio, 2023 • November 29, 2023
This review summarizes the current understanding of astrocyte-mediated inflammation in TSCI and the potential of nanomaterials to manage this inflammation. It classifies nanomaterials into organic, bi...
KEY FINDING: Organic nanomaterials, like PLGA nanoparticles, can effectively reduce the production of inflammatory factors by astrocytes and restrict glial scarring, improving behavioral performance in rats.
Neural Regeneration Research, 2024 • September 22, 2023
This review discusses the combination of stem cells (SCs) and 3D bioprinting scaffolds for the repair of spinal cord injury (SCI). It covers the mechanisms of stem cell therapy, different types of ste...
KEY FINDING: Stem cell therapy has the potential to repair damaged tissue in the spinal cord and promote the restoration of normal functionality in the nervous system due to their regenerative properties.
Journal of Tissue Engineering, 2024 • January 1, 2024
This study investigates the potential of XIST-overexpressing BMSCs to treat spinal cord injury (SCI) by modulating macrophage polarization and improving the neural stem cell (NSC) microenvironment. Th...
KEY FINDING: XIST overexpression in BMSCs promotes M2 macrophage polarization, suppressing inflammation in the SCI microenvironment.
Journal of Nanobiotechnology, 2024 • January 13, 2024
The study engineered HA-stabilized selenium nanoparticles (HA-Se NPs) specifically targeting the overexpressed CD44 receptor within the injured spinal cord, with the aim of mitigating secondary injury...
KEY FINDING: HA-Se NPs were easily prepared through direct reduction of seleninic acid in the presence of HA and exhibited a remarkable capacity to eliminate free radicals.
Iran. J. Biotechnol., 2023 • July 1, 2023
This study investigated the therapeutic potential of AD-MSC-DE encapsulated within collagen and fibrin hydrogels for treating spinal cord injury (SCI) in a rat model. The results demonstrated that AD-...
KEY FINDING: AD-MSC-DE encapsulated into fibrin and collagen hydrogels improved clinical function in SCI rats compared to the control group.
AMB Express, 2024 • January 31, 2024
The study aimed to improve the characteristics and efficiency of chondroitinase ABCI (chABCI) by immobilizing it on hydroxyapatite particles (HAPs). The results demonstrated that immobilized chABCI on...
KEY FINDING: Hydroxyapatite enhances the shelf life of chondroitinase when used as a carrier matrix.
BMC Cardiovascular Disorders, 2024 • March 1, 2024
This study compared 3D printing-assisted extracorporeal pre-fenestration TEVAR and castor-integrated branch stent techniques for treating Stanford type B aortic dissection with inadequate proximal anc...
KEY FINDING: The surgical success rate and device deployment success rate were 100% in both groups.
Polymers, 2024 • April 18, 2024
This study investigates the potential of a plasma-modified fibrillar scaffold (PLA + pPPy-I) to improve recovery after complete spinal cord transection in rats. The scaffold aims to provide structural...
KEY FINDING: The fibrillar composite scaffold moderated the structural effects of secondary damage by providing mechanical stability to the lesion core and supporting tissue reconstruction.
Materials Today Bio, 2024 • April 17, 2024
The study aimed to validate the in vitro and in vivo safety of adECM and adECM-rGO scaffolds in the context of neural tissue engineering strategies following SCI. In vitro testing included assessing s...
KEY FINDING: Both adECM and adECM-rGO scaffolds were cytocompatible in vitro, showing they are suitable for preclinical evaluation.
Sci. Adv., 2024 • May 8, 2024
This study introduces a flexible, thin-film bioelectronic device for circumferential interfacing with the spinal cord, enabling simultaneous recording and stimulation of neural signals from different ...
KEY FINDING: The flexible device allows for targeted stimulation of specific motor movements in the lower limbs by stimulating different regions of the ventrolateral spinal cord.