Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 411-420 of 12,052 results
International Journal of Nanomedicine, 2024 • December 12, 2024
This review discusses the potential of polymeric nanoparticles (NPs) as therapeutic agents for spinal cord injury (SCI), focusing on their immunomodulatory properties. The review emphasizes how the ph...
KEY FINDING: The size of NPs affects how they are taken up by cells, influencing the immune response. Smaller NPs tend to be internalized through different pathways than larger NPs.
Cureus, 2024 • December 12, 2024
This study investigated the safety and efficacy of autologous BM-MNC therapy in patients with CP, SCI, and MD, finding significant functional improvements and enhanced quality of life. The therapy app...
KEY FINDING: CP patients showed improved motor and cognitive function with reduced GMFCS scores (p<0.001).
Frontiers in Pharmacology, 2024 • December 12, 2024
The study investigates the molecular mechanisms of tomatidine in modulating the inflammatory response and promoting functional rehabilitation after SCI. Results show that tomatidine can alleviate neur...
KEY FINDING: Tomatidine promotes neuronal damage recovery and reduces histopathological changes in spinal cord tissues and LPS-induced PC-12 cells.
Frontiers in Pharmacology, 2024 • December 11, 2024
This study provides a bibliometric analysis of nanotechnology in SCI research, highlighting global research output, collaborative networks, and influential works. The analysis identifies China, the Un...
KEY FINDING: China and the United States are the leading countries in nanotechnology research for SCI, with China showing rapid growth in publications after 2019.
Frontiers in Neurology, 2024 • December 11, 2024
This pilot study provides proof-of-concept for the use of TRT + finasteride in men with SCI. The treatment showed promise in improving body composition and musculoskeletal health. The results suggest ...
KEY FINDING: TRT + finasteride consistently increased testosterone and estradiol, while concomitantly reducing dihydrotestosterone.
Cell Communication and Signaling, 2024 • December 11, 2024
This study investigates the role of UTX, an epigenetic regulator, in endothelial cells following spinal cord injury (SCI), focusing on its impact on neural stem cell (NSC) differentiation. The researc...
KEY FINDING: UTX knockout in spinal cord microvascular endothelial cells (SCMECs) enhances neurogenesis in a mouse model of spinal cord injury (SCI).
Human Brain Mapping, 2024 • December 11, 2024
This study presents a detailed methodology for targeting the hand representation in the somatosensory cortex using intracortical microstimulation (ICMS) to deliver tactile feedback for brain-computer ...
KEY FINDING: The study successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand in five participants with cervical spinal cord injury.
Front. Rehabil. Sci., 2024 • December 11, 2024
This study examined the relationship between functional independence and community integration among individuals with spinal cord injury (SCI) in Bangladesh following inpatient rehabilitation. The fin...
KEY FINDING: There was no statistically significant relationship between functional independence at discharge and community integration one month post-discharge.
Front. Neurosci., 2024 • December 11, 2024
This study investigates the analgesic effects of Dahuang Fuzi Decoction (DF) on neuropathic pain (NeP) using a rat model of chronic sciatic nerve compression injury (CCI). The research combines chemic...
KEY FINDING: DF treatment significantly increased the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI rats, indicating its analgesic effect.
Int. J. Mol. Sci., 2024 • December 11, 2024
Nanotechnology has emerged as a transformative force in neuroscience, addressing challenges that have long impeded progress in the diagnosis and treatment of CNS disorders. Theranostic NPs stand out a...
KEY FINDING: Nanoparticles can be engineered to cross the blood-brain barrier (BBB) using passive targeting, active targeting, and stimuli-responsive systems, enhancing drug delivery to the CNS.