Latest Research Summaries

KEY FINDING: DAM appear after motor neuron degeneration, primarily in the brain stem and spinal cord of ALS mice, and increase in number as the disease progresses, peaking in the late stage.

KEY FINDING: C2230 inhibits CaV2.2 channels in rat, marmoset, and human neurons in a G-protein-coupled-receptor–independent manner.

KEY FINDING: Stretching does not have clinically meaningful effects on joint mobility or reduce the risk of contractures in people with SCI.

KEY FINDING: NeuroStep partially restored lost sensations in all 14 PN participants through targeted neurostimulation at the ankle level.

KEY FINDING: During the first lockdown in the winter of 2020/2021, there was a notably lower incidence of moderate and severe TBIs compared to the corresponding period in 2019/2020 (p = 0.016).

KEY FINDING: LDLK3 monomers and AQP4 cause different structural perturbations in the neural membrane that may be interpreted as different lipid fingerprints.

KEY FINDING: hAECs exhibited uniform distribution and attachment to the scaffold. In vitro differentiation analyses showed increased expression of Calca, Fox3, MBP, and GFAP genes.

KEY FINDING: SCM-198 treatment resulted in a 100% survival rate in murine ALF models, even when administered 24 hours after ALF was established.

KEY FINDING: Radiomics can accurately differentiate between SCI patients and healthy controls. The machine learning model achieved an accuracy of 1.0 and an MCC of 0.97.

KEY FINDING: Frontal delta asymmetry positively correlates with depression symptoms, while frontal alpha asymmetry negatively correlates with anxiety symptoms.