Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11-20 of 12,052 results
Science Advances, 2025 • March 26, 2025
This study engineered Mms6 mRNA-loaded LNPs for targeted delivery to macrophages and investigated whether these LNPs could promote locomotor functional recovery following SCI. Intravenous administrati...
KEY FINDING: Mms6 mRNA-LNPs improved anti-ferroptosis capabilities of macrophages via managing the balance of cellular iron metabolism in a hypoxic condition, which is common in SCI.
Journal of Rehabilitation Medicine, 2025 • March 24, 2025
This qualitative study found that both patients and municipal physiotherapists valued participating in The Stroke School. Patients reported high motivation for exercise immediately after their stroke ...
KEY FINDING: Patients felt a sense of safety throughout the study due to close monitoring and follow-up sessions, which reassured them about being physically active.
Frontiers in Pharmacology, 2025 • March 24, 2025
This study investigated the therapeutic potential of pelargonidin, an anthocyanin, in a rat model of spinal cord injury (SCI). The primary focus was on assessing the impact of pelargonidin on sensorim...
KEY FINDING: Pelargonidin significantly attenuated neuropathic pain, improved motor performance, and reduced weight loss in rats with SCI.
J Physiol, 2025 • March 22, 2025
This study investigated the roles of the autonomic nervous system in cardiac dysfunction following spinal cord injury (SCI) in rats, finding that impaired sympathetic control is the primary driver. Th...
KEY FINDING: Impaired direct sympathetic transmission to the heart underlies the majority of the SCI-induced reduction in heart function post-SCI.
Frontiers in Neural Circuits, 2025 • March 21, 2025
This review focuses on three major descending pathways—the corticospinal tract (CST), rubrospinal tract (RbST), and reticulospinal tract (RtST)—summarizing their structures and functions, particularly...
KEY FINDING: The corticospinal tract (CST), rubrospinal tract (RbST), and reticulospinal tract (RtST) are three major descending pathways that serve as neural substrates for recovery.
World Journal of Urology, 2025 • March 21, 2025
The study examined the impact of botulinum toxin A detrusor injections (BoNT/A-DI) on blood pressure in patients with overactive bladder (OAB) or neurogenic bladder, focusing on cardiovascular risk fa...
KEY FINDING: Systolic blood pressure increased significantly by an average of 9.8 mmHg across all patients during the procedure.
Biology, 2025 • March 20, 2025
iPSCs have ushered in a new era in the field of SCI research, illuminating the intricate cellular and molecular mechanisms that underlie injury and recovery. Dedicated researchers are tirelessly worki...
KEY FINDING: iPSCs can be differentiated into various cell types that play crucial roles in SCI treatment, including neural progenitor cells, oligodendrocyte progenitor cells, astrocytes, and microglia.
Cureus, 2025 • March 20, 2025
This case series investigates the rapid reversal of forearm supinator rigidity using topical isomerized potassium linoleate (KCLA) in five patients diagnosed with vertigo of central origin. The study ...
KEY FINDING: Topical application of isomerized potassium linoleate (KCLA) rapidly reduced tenderness in the forearm supinator muscle within 2-4 minutes.
Cells, 2025 • March 20, 2025
The study aimed to determine the effectiveness of DFO in enhancing Schwann cell survival upon hydrogen peroxide-induced cell death in vitro, simulating clinical transplant conditions. The findings rev...
KEY FINDING: DFO increases Schwann cell survival in serum-containing medium following hydrogen peroxide challenge.
Frontiers in Physiology, 2025 • March 19, 2025
This study investigates the impact of spinal hypermobility on the development of ossification of the posterior longitudinal ligaments (OPLL) using an in vivo mouse model. The researchers induced hyper...
KEY FINDING: Spinal hypermobility accelerates the progression of ossification in mice with heterotopic ossification of spinal ligaments.