Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 221-230 of 12,052 results
Scientific Reports, 2025 • January 17, 2025
This study evaluated a novel method of personalized robot-assisted training for motor skills, based on error probability. The key contribution of EF was that error the augmentation is small only if th...
KEY FINDING: Training with error fields (EF) resulted in the lowest steady-state error, outperforming both control and error augmentation (EA) groups.
CNS Neuroscience & Therapeutics, 2025 • January 17, 2025
Existing studies have shown that Sirt1 plays a core role in neuroprotection and tissue repair by regulating inflammatory response, oxidative stress, autophagy, and mitochondrial function. Sirt1 can me...
KEY FINDING: Sirt1 exerts broad regulatory effects across diverse pathological processes and cell types post-SCI. It promotes neuronal survival and axonal regeneration, modulates astrocytes and microglia to resolve inflammation, supports oligodendrocyte-mediated myelination, and enhances vascular endothelial function.
Int. J. Mol. Sci., 2025 • January 16, 2025
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic strategy for spinal cord injury (SCI) due to their unique properties like low immunogenicity and ...
KEY FINDING: MSC-EVs have been demonstrated to exert multiple beneficial effects in SCI, including reducing inflammation, promoting neuroprotection, and enhancing axonal regeneration.
Journal of Orthopaedic Surgery and Research, 2025 • January 16, 2025
This study investigated the impact of simulated overload and microgravity on intervertebral disc degeneration in rabbits. The researchers focused on the expression of MMP1, MMP3, and TIMP1. The study ...
KEY FINDING: MMP1 and MMP3 expression increased significantly in experimental groups compared to controls. The increase correlated with longer exposure to simulated overload and microgravity.
Cureus, 2025 • January 16, 2025
This case highlights the vast diversity of pediatric spinal tumors and their potential for favorable postoperative outcomes. It also provides evidence for the existence of benign, fibrolipomatous infl...
KEY FINDING: The patient had an extensive extradural, intracanal mass from T1 to T10 causing spinal cord compression.
JMIR Rehabilitation and Assistive Technology, 2025 • January 16, 2025
This pilot study investigated the feasibility of using multiparametric MRI (mpMRI) to assess the effects of a 6-month FES-cycling training program on muscle health in individuals with complete spinal ...
KEY FINDING: Muscle volume increased by an average of 22.3% at 3 months and 36.7% at 6 months compared to baseline, remaining 23.2% higher one month post-training.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
Journal of Craniovertebral Junction and Spine, 2024 • January 15, 2025
The study compared radiographic outcomes and subsidence rates between hyperlordotic and standard lordotic interbody spacers in ACDF patients. Hyperlordotic spacers led to increased cervical lordosis a...
KEY FINDING: Hyperlordotic spacers resulted in a significantly higher cervical lordosis (CL) at 1-year post-surgery compared to standard lordotic spacers.
Journal of Neurology, 2025 • January 15, 2025
This case report describes a patient with cervical spinal cord injury who developed propriospinal myoclonus (PSM), a rare movement disorder characterized by involuntary trunk muscle jerks. The authors...
KEY FINDING: A 38-year-old male developed PSM 48 weeks after a C3 spinal cord injury, characterized by trunk muscle jerks at a frequency of 0.4–0.6 Hz.
Bioengineering, 2025 • January 15, 2025
This study investigated the effect of adapted rowing ergometer setup and speed on lower extremity loading in a group of able-bodied adults and a single participant with SCI. The hypotheses were suppor...
KEY FINDING: Able-bodied rowers generated 0.22–0.45 body weight foot reaction forces, and higher forces were associated with faster speeds, a forward seat position, and a large knee range of motion.