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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 231-240 of 12,052 results

Spinal Cord InjuryHealthcareRehabilitation

Exploring barriers to rehabilitation for individuals with spinal cord injury: a qualitative study in Iran

BMC Health Services Research, 2025 • January 15, 2025

This study explores barriers to rehabilitation services for individuals with spinal cord injuries in Golestan province, Iran, identifying personal, provider-related, and socio-supportive factors. The ...

KEY FINDING: Personal limiting factors include insufficient health literacy and inadequate home adaptations.

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Spinal Cord InjuryImmunologyGenetics

Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS

Frontiers in Immunology, 2025 • January 15, 2025

This study demonstrates that low-level spinal cord injury (SCI) enhances lung inflammation and immune responses in mice exposed to lipopolysaccharide (LPS), mimicking a bacterial infection. SCI amplif...

KEY FINDING: Spinal cord injury (SCI) at the T9 level amplifies lung inflammation in mice following exposure to lipopolysaccharide (LPS), as evidenced by increased pro-inflammatory gene expression and cytokine release.

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Spinal Cord InjuryNeurologyNeurorehabilitation

Non‑invasive cerebral and spinal cord stimulation for motor and gait recovery in incomplete spinal cord injury: systematic review and meta‑analysis

Journal of NeuroEngineering and Rehabilitation, 2025 • January 15, 2025

This systematic review and meta-analysis aimed to compare the effect of non-invasive cerebral and spinal cord stimulation on gait recovery and motor strength of lower limbs in subjects with SCI. The r...

KEY FINDING: Non-invasive central nervous system stimulation had significant effects on Lower Extremity Motor Scale (LEMS) score and gait speed when all studies were pooled together.

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Spinal Cord InjuryHealthcareRehabilitation

Therapeutic path of Brazilians with spinal cord injury until rehabilitation

Scientific Reports, 2025 • January 15, 2025

This quantitative, exploratory, analytical, and cross-sectional study evaluated the therapeutic path of 618 Brazilian adults with spinal cord injury (SCI). The study found that a significant proportio...

KEY FINDING: The mean time to start rehabilitation after SCI was 17.68 months, with a significant percentage of participants not undergoing any rehabilitation.

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PhysiologyPain ManagementGenetics

NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors

Scientific Reports, 2025 • January 14, 2025

This study investigates the therapeutic effect of NaHS on neuropathic pain using the spared nerve injury (SNI) model in mice, focusing on astrocytes and glutamate. The findings reveal that NaHS enhanc...

KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.

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Spinal Cord InjuryHealthcareBioinformatics

A multi-analyte blood test for acute spinal cord injury

The Journal of Clinical Investigation, 2025 • January 14, 2025

This study introduces a multi-analyte blood test for acute SCI, utilizing spinal cord–derived cfDNA and plasma protein alterations to inform diagnosis and prognosis. The Spinal Cord Injury Index (SCII...

KEY FINDING: A ddPCR assay detected spinal cord–derived cfDNA in plasma of 50 patients with acute SCI (AUC: 0.89, 95% CI 0.83–0.95, P < 0.0001).

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Spinal Cord InjuryAssistive TechnologyRehabilitation

Effect of a virtual walking and exercise-based intervention on muscle strength and activation in people with incomplete spinal cord injury

Scientific Reports, 2025 • January 14, 2025

This study assessed the impact of combining virtual walking (VW) therapy with a physical exercise (PE) program on lower limb strength and muscle activation in individuals with incomplete spinal cord i...

KEY FINDING: The Experimental Intervention (EI) group exhibited a general strength increase after the intervention, ranging from 16.31 to 34.72 N, and maintained this improvement for hip abduction and extension movements up to a 1-month follow-up.

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Spinal Cord InjuryNeurologyRehabilitation

Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training

Frontiers in Human Neuroscience, 2025 • January 14, 2025

This case study investigated the effects of robot-assisted task-oriented bimanual training (RBMT) on upper limb function, activities of daily living, and movement-related sensorimotor activity in a pa...

KEY FINDING: Robot-assisted bimanual training (RBMT) improved the patient’s upper limb motor function and activity independence.

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Pain ManagementBioinformaticsRehabilitation

Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain

Scientific Reports, 2025 • January 13, 2025

This study explores the protective effect of prior exercise against neuropathic pain (NP) in rats by examining protein expression changes in the spinal dorsal horn using proteomic analysis. The findin...

KEY FINDING: Prior exercise significantly increased the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in rats with CCI, indicating a reduction in pain sensitivity.

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AgingGeneticsOrthopedics

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, 2025 • January 12, 2025

This study aimed to explore the role of aging and circadian rhythm-related genes in knee osteoarthritis (KOA). Differentially expressed genes (DEGs) were identified from the GEO database and intersect...

KEY FINDING: Identified 75 differentially expressed aging-circadian rhythm related genes between normal and KOA groups, primarily enriched in the circadian rhythm pathway.

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