Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 171-180 of 12,052 results
Journal of Neuroinflammation, 2025 • January 28, 2025
This study identifies heterogeneous nuclear ribonucleoprotein U (Hnrnpu) as a potential endogenous molecule that regulates astrocyte proliferation and the following scar formation. Inhibition of Hnrnp...
KEY FINDING: Hnrnpu promotes astrocyte reactivity. Inhibiting Hnrnpu suppresses astrocyte migration and alters expression of the genes associated with astrocyte reactivity in vitro.
J. Clin. Med., 2025 • January 28, 2025
This case report examined the impact of Comb-NMES on muscle glucose signaling, fiber type distribution, and metabolic function in a patient with acute SCI and LMNLs. The Comb-NMES intervention led to ...
KEY FINDING: The intervention led to a 74.7% reduction in fasting insulin levels and a 28.2% reduction in fasting glucose levels, indicating improved metabolic control.
Frontiers in Neuroscience, 2025 • January 28, 2025
This investigation presents a bibliometric analysis of CST regeneration, underscoring the pivotal role of the United States as a leader in this scientific domain. Our findings unveiled the dynamics an...
KEY FINDING: The 100 most cited publications were published between 2004 and 2020, amassing 18,321 citations, with individual citation counts ranging from 83 to 871.
Bioactive Materials, 2025 • January 27, 2025
This review article explores the application of MXenes, a class of two-dimensional nanomaterials, in the repair and regeneration of electroactive tissues and organs. It highlights MXenes' unique physi...
KEY FINDING: MXene microelectrodes yielded higher quality neural recordings compared to gold microelectrodes due to lower neural impedance and background noise.
Translational Neuroscience, 2025 • January 27, 2025
This study investigates the role of Netrin-1 and its receptor DCC in promoting axonal regeneration and functional recovery after spinal cord injury (SCI) in rats. The findings suggest that Netrin-1, b...
KEY FINDING: SCI injury decreases the expression of Netrin-1 in spinal cord tissue, suggesting Netrin-1 plays a role after SCI.
Materials Today Bio, 2025 • January 27, 2025
This study successfully fabricated 3D-printed Ga-MBG/TCP scaffolds with interconnected porous structures and controlled gallium ion release. In vitro experiments demonstrated that the Ga-MBG/TCP compo...
KEY FINDING: The 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis.
eLife, 2024 • January 27, 2025
This study combined computational modeling and experimental approaches to investigate the effects of a lateral thoracic hemisection on spinal sensorimotor circuits controlling locomotion in cats. The ...
KEY FINDING: During tied-belt locomotion, the contralesional hindlimb's speed-dependent changes were similar to intact conditions, while the ipsilesional hindlimb showed shorter stance and longer swing phases.
Theranostics, 2025 • January 27, 2025
The study successfully synthesized NABDM using coaxial electrospinning technology, creating core-shell structured nano-fiber/nets. This structure ensures time-specific drug release and improves mechan...
KEY FINDING: NABDM modifies the polarization direction of microglia in vitro, and promotes the differentiation of NSCs by activating the cGMP–PKG and cAMP signaling pathways.
bioRxiv preprint, 2025 • January 27, 2025
This study introduces EPISeg, a deep learning-based method for automated spinal cord segmentation on gradient-echo EPI images, commonly used in fMRI. EPISeg addresses challenges related to heterogeneo...
KEY FINDING: EPISeg significantly improves spinal cord segmentation quality compared to existing methods.
Journal of Neuroinflammation, 2025 • January 27, 2025
This study demonstrates a significant upregulation of C/EBPβ in microglia in a mouse model of SCI, suggesting its involvement in the post-SCI neuroinflammatory response. The research uncovers that C/E...
KEY FINDING: C/EBPβ is significantly upregulated in microglia after spinal cord injury in mice and is associated with neuroinflammation.