3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration

This study addresses the challenge of treating osteoporotic bone defects, which are often complicated by osteolysis (bone breakdown). The research team developed a 3D-printed scaffold infused with gallium to combat osteolysis and promote bone regeneration. The scaffold combines the osteogenic potential of mesoporous bioactive glass (MBG) and β-tricalcium phosphate (β-TCP) with the anti-bone resorption property of Ga doping. Different concentrations of Ga-MBG were incorporated into β-TCP to create composite scaffolds. The composite scaffolds were tested in vitro for cytocompatibility and their effects on osteoblast and osteoclast differentiation. The optimal concentration of Ga-MBG/TCP composite scaffold was then evaluated in a rat model of cranial defects associated with osteoporosis to assess its therapeutic efficacy and biological safety.

• 1
  The 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis.
• 2
  Increasing the doping amount of Ga-MBG enhances the mechanical properties of the scaffolds.
• 3
  The 10 wt% Ga-MBG/TCP scaffold most effectively promoted cell migration.