Translational Neuroscience, 2025 · DOI: https://doi.org/10.1515/tnsci-2025-0365 · Published: January 27, 2025
Spinal cord injury (SCI) causes disabilities due to lack of neurotrophic factors and presence of inhibitory factors for axonal regeneration. This study investigates Netrin-1's role in promoting axonal regeneration by binding to the DCC receptor after SCI. A Netrin-1/DCC co-expression lentiviral vector was constructed to assess the effect of Netrin-1 on the NgR1-RhoA-ROCK signaling pathway in an SCI model. Results suggest that Netrin-1 has neuroprotective effects by inhibiting this pathway after binding to DCC. The study aims to understand the mechanisms by which Netrin-1 promotes axon regeneration and regulates the NgR1-RhoA-ROCK signaling pathway after nerve injury, potentially opening new avenues for clinical treatment of SCI.
Netrin-1/DCC and NgR1-RhoA-ROCK signaling pathway may be potential therapeutic targets for SCI.
The study supports the development of bio-repair strategies based on promoting Netrin-1/DCC interaction to stimulate axon growth.
The findings open new avenues for clinical treatment of SCI by targeting the NgR1-RhoA-ROCK pathway.