A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024

Frontiers in Neuroscience, 2025 · DOI: 10.3389/fnins.2024.1509850 · Published: January 28, 2025

Spinal Cord Injury Neurology Research Methodology & Design

Simple Explanation

This study employs bibliometric and visual analytical techniques to assess the characteristics of the 100 most cited publications focusing on corticospinal tract (CST) regeneration. The research identifies key trends, patterns, and contributors in CST regeneration research by analyzing data from the Web of Science Core Collection. The analysis covers a 20-year period (2004 to 2024) to provide a comprehensive overview of advancements and dynamics in the field of CST regeneration.

Study Duration

20 Years

Participants

Not specified

Evidence Level

Review

Key Findings

1
The 100 most cited publications were published between 2004 and 2020, amassing 18,321 citations, with individual citation counts ranging from 83 to 871.
2
Schwab M. E., is the most prominent contributor, with significant authorship in 9 of the 100 papers, and the United States led the geographical distribution with 49 articles.
3
Keyword analysis revealed themes like optic nerve, gene expression, CST integrity/regeneration, diffusion tensor imaging, myelin-associated glycoproteins, neurite outgrowth inhibitors, and electrical/intracortical microstimulation methods.

Research Summary

This investigation presents a bibliometric analysis of CST regeneration, underscoring the pivotal role of the United States as a leader in this scientific domain. Our findings unveiled the dynamics and trends within the field of CST regeneration, providing a scientific foundation for clinical applications. Our analysis indicated that the application of CST regeneration in the clinic should be optimized through interdisciplinary collaboration, enabling the exploration and validation of a variety of therapeutic approaches.

Practical Implications

Interdisciplinary Collaboration

Optimize clinical applications of CST regeneration by fostering collaboration across disciplines.

Therapeutic Approach Validation

Explore and validate therapeutic approaches like neurotrophic factors, stem cell therapies, biomaterials, and electrical stimulation.

Clinical Trials and Assessment Tools

Conduct clinical trials to test therapeutic safety/efficacy and develop tools for monitoring patient recovery.

Study Limitations

1
The Web of Science does not include all existing publications.
2
Relying on citation frequency might exclude recently published works.
3
There is a possibility of citation bias from renowned institutions or authors.

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