Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,991-12,000 of 12,052 results
The Journal of Neuroscience, 2005 • August 31, 2005
The study investigates strategies to promote sensory axon regeneration in the injured spinal cord, focusing on overcoming inhibitory factors and enhancing neuronal growth capacity. The key finding is ...
KEY FINDING: Inflammation-induced preconditioning of sensory neurons combined with enzymatic degradation of inhibitory proteoglycans (CSPGs) significantly enhances axonal regeneration through the DREZ.
International Orthopaedics (SICOT), 2005 • August 11, 2005
This study examined the outcomes of spinal cord injury (SCI) patients in Sierra Leone, a country with limited resources and a struggling healthcare system. The research tracked 24 patients admitted to...
KEY FINDING: The hospital mortality rate was 29.2% during the 18-month study period.
Eur J Neurosci, 2005 • August 1, 2005
The study investigates the combined effects of methylprednisolone (MP) and soluble Nogo-66 receptor (NgR) on spinal cord injury (SCI) recovery in rats, using a dorsal hemisection model. Both MP and Ng...
KEY FINDING: Combined treatment with NgR(310)ecto-Fc and MP had a more pronounced effect on recovery of function and axonal growth compared with either treatment alone.
PNAS, 2005 • July 26, 2005
The study identifies ephrin-B3, a developmental axon guidance molecule, as a myelin-based inhibitor of neurite outgrowth in the adult spinal cord. Ephrin-B3 is expressed in myelinating oligodendrocyte...
KEY FINDING: Ephrin-B3 is expressed in postnatal myelinating oligodendrocytes in the mouse spinal cord, suggesting a role in myelin-based inhibition of axon outgrowth.
J Orthop Sci, 2005 • June 28, 2005
The editorial emphasizes the importance of intuition in scientific research, particularly in the field of orthopedics, alongside logic and objective analysis. It also stresses the need for researchers...
KEY FINDING: Excellent research results cannot be obtained through logicality alone; research intuition is also necessary.
J Control Release, 2005 • June 2, 2005
This report, single lumen and multiple lumen conduits capable of controlled, sustained release of neurotrophic factors were fabricated, and have potential application in nerve regeneration. These cond...
KEY FINDING: The porosity and mechanical properties of the constructs were regulated by the ratio of porogen to polymer microsphere.
Nat Neurosci, 2005 • June 1, 2005
This study investigates the role of XTRPC1, a calcium channel, in neuronal growth cone guidance in Xenopus spinal neurons. The findings demonstrate that XTRPC1 is required for growth cone turning resp...
KEY FINDING: XTRPC1 is required for the proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor (BDNF), and myelin-associated glycoprotein (MAG).
Journal of NeuroEngineering and Rehabilitation, 2005 • May 31, 2005
This study systematically compares a traditional linear muscle model and two contemporary nonlinear models using sensitivity analysis to examine how each model's parameters influence select simulated ...
KEY FINDING: The linear model parameters clearly influence either simulated force magnitude or speed properties, consistent with previous parameter definitions.
Spinal Cord, 2005 • May 1, 2005
The study examined how pain changes during recovery from spinal cord injury (SCI) and its relationship with community integration. A significant proportion of individuals with SCI reported pain at 6 m...
KEY FINDING: 86% of individuals with SCI reported pain at 6 months post-discharge, with 27% reporting pain impacting many or most activities.
J Neurol Neurosurg Psychiatry, 2005 • May 1, 2005
This study demonstrates that systematic collection, analysis, and interpretation of standardised clinical outcomes data are feasible within routine clinical practice. Inpatient rehabilitation is effec...
KEY FINDING: Patients in the neurorehabilitation unit showed improvements in functional ability, as measured by the Barthel Index (BI) and Functional Independence Measure (FIM).