Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury

This study explores treatments for spinal cord injury (SCI) using methylprednisolone (MP) and a soluble Nogo-66 receptor (NgR). MP reduces inflammation, while NgR promotes nerve regeneration. The experiment involved rats with SCI, where researchers administered MP and NgR separately and together. Functional recovery was monitored using behavioral scores and footprint analysis. Results showed that combining MP and NgR led to better functional recovery and axonal growth compared to using either treatment alone, suggesting these treatments work in distinct yet complementary ways.

• 1
  Combined treatment with NgR(310)ecto-Fc and MP had a more pronounced effect on recovery of function and axonal growth compared with either treatment alone.
• 2
  MP treatment had an early effect on recovery, while NgR(310)ecto-Fc's effect was noticeable later, suggesting different mechanisms of action.
• 3
  The number of axons contacting α- and/or γ-motor neurons was significantly increased in all treatment groups compared with control animals