Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 12,001-12,010 of 12,052 results
Mol Cell Neurosci, 2005 • May 1, 2005
This study demonstrates that transgenic expression of a secreted function-blocking NgR protein has profound effects after SCI, stimulating both CST and raphespinal fiber growth in the injured spinal c...
KEY FINDING: Transgenic mice expressing NgR(310)ecto showed increased CST fiber growth into the caudal spinal cord after dorsal over-hemisection compared to wild-type mice.
Cellular and Molecular Neurobiology, 2005 • April 1, 2005
The study comprehensively screens for genes that change their expression during the brief critical period in development when the neonatal mammalian central nervous system (CNS) loses its capacity to ...
KEY FINDING: The study identified a set of genes that are differentially expressed in regenerating versus non-regenerating spinal cords of neonatal opossums, including novel sequences and genes involved in cell growth, motility, and myelin formation.
Exp Neurol, 2005 • March 1, 2005
The study examined the response of endogenous oligodendrocyte precursor cells (OPCs) following ethidium bromide (EB)-induced demyelination of the adult rat spinal cord. A robust mobilization of highly...
KEY FINDING: Nkx2.2+/Olig2+ OPCs are recruited to demyelinated lesions but fail to remyelinate axons in regions lacking astrocytes.
The Journal of Neuroscience, 2005 • February 16, 2005
This study investigates the role of STAT3 activation in conditioning injury-induced spinal axon regeneration. The researchers found that sciatic nerve transection, but not dorsal column crush, leads t...
KEY FINDING: Sciatic nerve transection induces persistent STAT3 phosphorylation in DRG neurons in vivo, while dorsal column crush does not.
Disabil Rehabil, 2005 • February 4, 2005
This case report describes a standing and surveillance system that allows quantification of standing dose. Preliminary investigation with a single subject indicates that compliance with this device is...
KEY FINDING: The client exceeded a suggested minimum dosage of standing per month (130.4% of goal).
The Journal of Neuroscience, 2005 • February 2, 2005
The study investigates a combinatory strategy to promote axonal regeneration and functional recovery after complete spinal cord transection in adult rats. The treatment involved reducing inhibitory cu...
KEY FINDING: The combination of SC bridge, olfactory ensheathing glia, and chondroitinase ABC provided significant benefit compared with grafts only or the untreated group.
Postgrad Med J, 2005 • February 1, 2005
This article traces the history of spinal injury treatment from ancient times to the modern era, highlighting key figures and developments in the field. The development of specialized spinal units and...
KEY FINDING: Early management of spinal injuries focused on traction and laminectomy, but outcomes remained poor due to complications such as renal failure.
BMC Dermatology, 2004 • December 15, 2004
This study compared hydrocolloid dressings (HD), phenytoin cream (PC), and simple dressings (SD) for treating stage I and II pressure ulcers in 83 paraplegic male war veterans. The results indicated t...
KEY FINDING: Hydrocolloid dressings showed better complete healing rates for all ulcers (regardless of stage or location) compared to phenytoin cream and simple dressings.
Ann N Y Acad Sci, 2004 • December 1, 2004
Rehabilitation seeks to reduce impairments from neurological conditions using the brain's plasticity. It leverages biological changes after injury and external factors to influence neural pathways. Th...
KEY FINDING: The cortex in humans contributes to reaching, grasping, individuated finger movements, and walking-related motor control.
The Journal of Neuroscience, 2004 • November 10, 2004
This study demonstrates that mice lacking EphA4 exhibit axonal regeneration and functional recovery after spinal cord injury, including improved motor skills. The absence of EphA4 leads to reduced ast...
KEY FINDING: EphA4-deficient mice exhibit axonal regeneration and functional recovery after spinal cord hemisection, including improvements in stride length, grid walking, and grasping ability.