Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,681-11,690 of 12,052 results
Molecular Therapy, 2009 • June 1, 2009
This study investigates a combination of microsurgery and gene therapy to repair spinal dorsal root injuries, common in brachial plexus injuries. Microsurgery restores anatomical continuity, while gen...
KEY FINDING: Microsurgery combined with gene therapy promotes efficient axonal regrowth of DR ganglion central axons into the spinal cord.
Spinal Cord, 2009 • June 1, 2009
This review examined six instruments used to measure participation in individuals with SCI, evaluating their measurement properties such as reliability and validity. The CHART demonstrated the most ro...
KEY FINDING: Six instruments were included: Craig Handicap Assessment and Reporting Technique (CHART); Impact on Participation and Autonomy Questionnaire (IPA); Assessment of Life Habits Scale (Life-H); Occupational Performance History Interview (OPHI); Physical Activity Recall Assessment for People with Spinal Cord Injury (PARA-SCI); and Reintegration to Normal Living Index (RNL).
Neurorehabil Neural Repair, 2009 • June 1, 2009
This study examines swimming as a task-specific model for locomotor retraining after spinal cord injury in rats. The researchers quantitatively analyzed hindlimb kinematics before and after injury, an...
KEY FINDING: Uninjured rats exhibit consistent swimming kinematics, indicating that hindlimb movement doesn't change over time when first exposed to water as adults, suggesting the swimming pattern is hardwired.
Brain Res, 2009 • June 1, 2009
The study investigates changes in the γ2 subunit of GABAA receptors in muscle-specific motoneurons and astrocytes following spinal cord transection and motor training in rats. Researchers found that s...
KEY FINDING: Spinal rats had higher levels of γ2 in TA (tibialis anterior, ankle flexor) motoneurons and lower levels in soleus (ankle extensor) motoneurons compared to intact rats.
BMC Public Health, 2009 • June 1, 2009
This study investigates the barriers and facilitators to physical activity among individuals with spinal cord injury (SCI). The research highlights the importance of both motivational and socio-enviro...
KEY FINDING: Both exercisers and non-exercisers recognized motivation as crucial for maintaining an active lifestyle, but non-exercisers often perceived a 'limited return on investment' from exercise.
J Biomech, 2009 • May 29, 2009
The study developed an ANN-based technique to predict end-point limb motions using neuromuscular activity feedback from individuals with interrupted spinal cords. Experimental results confirmed the hi...
KEY FINDING: The ANN-based technique achieved highly accurate predictions for altered end-point locomotion (R-values of 0.92 – 0.97).
The Journal of Neuroscience, 2009 • May 13, 2009
The study demonstrates that blocking Nogo receptor ligands with sNgR promotes the regeneration of myelinated sensory axons after dorsal root crush in adult rats. sNgR treatment leads to the regrowth o...
KEY FINDING: Intraventricular infusion of sNgR for 1 month results in extensive regrowth of myelinated sensory axons into the white and gray matter of the dorsal spinal cord.
British Journal of Pharmacology, 2009 • May 5, 2009
Traumatic brain injury (TBI) is a major public health problem lacking effective drug treatments. Progress in spinal cord injury research provides optimism for developing neuroregenerative therapies fo...
KEY FINDING: Axonal retraction bulbs are dynamic structures, not static markers of failed regeneration, suggesting they can be therapeutically targeted.
Exp Neurol, 2009 • May 1, 2009
This study investigates the expression of myelin inhibitors Nogo-A and MAG during oligodendrogliogenesis and their effects on neurite outgrowth. The findings reveal that OPCs express Nogo-A but not MA...
KEY FINDING: OPCs express the intracellular domain of Nogo-A but not MAG, while mature oligodendrocytes express both.
Orthopaedic Surgery, 2009 • May 1, 2009
This study evaluated the efficacy of cell therapy using fetal spinal cord cells (FSCC) and/or Schwann cells (SC), with or without growth factors (NGF and BDNF), in a rat model of spinal cord injury. T...
KEY FINDING: A combination of FSCC and SC resulted in better recovery than either cell type alone, suggesting a synergistic effect.